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FabGennix/Bestrophin 3 Antibody/BEST-301AP

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DescriptionPublicationsbody { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }.BalloonText { margin-bottom:0pt; line-height:normal; font-family:Tahoma; font-size:8pt }span.BalloonTextChar { font-family:Tahoma; font-size:8pt }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }General InformationProductBestrophin 3 AntibodyVerified ApplicationsCM, ELISA, IF, IHC, IP, WBHostRabbitSpecies Cross ReactivityMouse, RatImmunogenSynthetic peptide taken within the last 50 amino acids from the C-terminus of rat Bestrophin-3 protein.Physical PropertiesQuantity100 µgVolume200 µlConcentration0.5 µg/µl in antibody stabilization bufferFormAffinity PurifiedClonalityPolyclonalStorage-20⁰C for long term storageApplication ProtocolConfocal Microscopy1:200DB1:10,000ELISA1:10,000Immunocytochemistry1:200Immunofluorescence1:200Immunohistochemistry1:200Immunoprecipitation1:200Western Blot1:500-1:1,000ProteinUniprot #Q6H1V1OverviewForms calcium-sensitive chloride channels. Permeable to bicarbonate.Molecular FunctionIon transport; Calcium, Chloride.Subcellular LocationCell membrane; Multi-pass membrane protein.ExpressionSkeletal muscle and weakly in brain, spinal cord, bone marrow and retina.StructureBelongs to bestrophin FamilyAlternative NomenclatureBEST 3 antibodyBestrophin3 antibodyMGC13168 antibodyMGC40411 antibodyVitelliform macular dystrophy 2-like protein 3 antibodyVMD2L3 antibodyProtein information supplied by UniProtbody { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }Fabgennix Bestrophin 3 Antibody has been used in 6 PublicationsGolubinskaya, V., et al. "Bestrophin‐3 is differently expressed in normal and injured mouse glomerular podocytes."Acta Physiologica(2015). PMID25912364Electron Microscopy, Immunodepletion, Western Blot; MouseJiang, Lei, et al. "Mitochondria dependent pathway is involved in the protective effect of bestrophin-3 on hydrogen peroxide-induced apoptosis in basilar artery smooth muscle cells." Apoptosis 18.5 (2013): 556-565. PMID23468120 Western Blot; RatLee, Wing-Kee, et al. "ERK1/2-dependent bestrophin-3 expression prevents ER-stress-induced cell death in renal epithelial cells by reducing CHOP." Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1823.10 (2012): 1864-1876. PMID22705154Immunofluorescence, Western Blot; RatWang, Mi, et al. "Downregulation of TMEM16A calcium-activated chloride channel contributes to cerebrovascular remodeling during hypertension by promoting basilar smooth muscle cell proliferation." Circulation 125.5 (2012): 697-707. PMID22215857Western Blot; RatBroegger, Torbjoern, et al. "Bestrophin is important for the rhythmic but not the tonic contraction in rat mesenteric small arteries." Cardiovascular research 91.4 (2011): 685-693. PMID21498420Immunofluorescence, Immunohistochemistry, Western Blot; RatMatchkov, Vladimir V., et al. "Bestrophin-3 (Vitelliform Macular Dystrophy 2–Like 3 Protein) Is Essential for the cGMP-Dependent Calcium-Activated Chloride Conductance in Vascular Smooth Muscle Cells." Circulation research 103.8 (2008): 864-872. PMID18776041 Western Blot; RatPublishing research using BEST-301AP? Please let us know, we can cite the reference in this datasheet.

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