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FabGennix/CCR4 Antibody/CCR4-401AP
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Descriptionbody { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }.BalloonText { margin-bottom:0pt; line-height:normal; font-family:Tahoma; font-size:8pt }.ListParagraph { margin-left:36pt; margin-bottom:10pt; line-height:115%; font-size:11pt }span.BalloonTextChar { font-family:Tahoma; font-size:8pt }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }General InformationProductCCR4 AntibodyDescriptionAffinity Purified C-C chemokine receptor type 4 Antibody Verified ApplicationsCF, DB, ELISA, IF, IHC, IP, WBHostRabbitSpecies Cross ReactivityCat, Human, Monkey, Mouse, RatImmunogenSynthetic peptide taken within amino acid region 1-50 on human C-C chemokine receptor type 4 protein.Accession #NCBI: NP_005499Physical PropertiesQuantity100 µgVolume200 µlConcentration0.68 µg/µl in antibody stabilization bufferFormAffinity PurifiedClonalityPolyclonalStorage-20⁰C for long term storageApplication ProtocolConfocal Microscopy1:250Immunocytochemistry1:250Immunofluorescence1:250Immunohistochemistry1:250Immunoprecipitation1:250Western Blot1:500ProteinUniprot #P51679OverviewReceptor for C-C type chemokines CCL17/TARC and CCL22/MDC. Functions as chemoattractant homing receptor on circulating memory lymphocytes and as coreceptor for some primary HIV-2 isolates. Can also mediate hippocampal-neuron survival.Molecular FunctionGPCR, Receptor, Transducer.Subcellular LocationCell membrane; Multi-pass membrane proteinExpressionThymus, peripheral blood leukocytes including T-cells, CD4+ cells, basophils and in platelets. Expressed less in spleen and in monocytes. Also found in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expresseding cutaneous lymphocyte antigen. Expressed in brain and microvascular and coronary artery endothelial cells.StructureBelongs to G-protein coupled receptor 1 family. Interacts with CREB3.Alternative NomenclatureCD194 antibodyChemR13 antibodyCKR4 antibodyCMKBR 4 antibodyHGCN 14099 antibodyK5 5 antibodyProtein information supplied by UniProt

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