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FabGennix/CD86 Antibody/CD86-101AP
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Descriptionbody { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }.BalloonText { margin-bottom:0pt; line-height:normal; font-family:Tahoma; font-size:8pt }span.BalloonTextChar { font-family:Tahoma; font-size:8pt }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }General InformationProductCD86 Antibody Affinity PurifiedDescriptionAffinity Purified T-lymphocyte activation antigen CD86 isoform 1 precursor Antibody Verified ApplicationsELISA, WBHostRabbitSpecies Cross ReactivityHumanImmunogenSynthetic peptide taken within amino acid region 250-329 on human CD86 protein.Accession #NCBI: NP_787058Physical PropertiesQuantity100 µgVolume200 µlConcentration0.50-0.75 µg/µl in antibody stabilization bufferFormAffinity PurifiedClonalityPolyclonalStorage-20⁰C for long term storageApplication ProtocolDB1:20,000ELISA1:20,000Western Blot1:500ProteinUniprot #P42081OverviewReceptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation.Molecular FunctionReceptor; Adaptive Immunity; Host-virus interaction; ImmunitySubcellular LocationCell membrane; Single-pass type I membrane proteinExpressionExpressed by activated B-lymphocytes and monocytes.StructureContains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 Ig-like V-type (immunoglobulin-like) domain.Alternative NomenclatureActivation B7 2 antigen antibodyB-lymphocyte activation antigen B7-2 antibodyB7 2 antibodyB70 antibodyBU63 antibodyCD 86 antibodyCD28 antigen ligand 2 2 antibodyCLS1 antibodyCTLA 4 counter receptor B7 2 antibodyEarly T-cell costimulatory molecule 1 antibodyETC-1 antibodyFUN 1 antibodyLAB72 antibodyLy-58 antibodyMB7-2 antibodyMembrane glycoprotein antibodyMGC34413 antibodyT-lymphocyte activation antigen CD86 antibodyTS/A-2 antibodyProtein information supplied by UniProt

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