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FabGennix/CXCR7 Antibody/CXCR7-701AP

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CXCR7-701AP

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Descriptionbody { line-height:115%; font-family:Calibri; font-size:11pt }p { margin:0pt 0pt 10pt }table { margin-top:0pt; margin-bottom:10pt }.BalloonText { margin-bottom:0pt; line-height:normal; font-family:Tahoma; font-size:8pt }span.BalloonTextChar { font-family:Tahoma; font-size:8pt }span.Hyperlink { text-decoration:underline; color:#0000ff }.TableGrid { margin-bottom:0pt; line-height:normal }General InformationProductCXCR7 AntibodyDescriptionAffinity Purified Chemokine (C-X-C motif) receptor 7 Antibody Verified ApplicationsELISA, IHC, IP, WBHostRabbitSpecies Cross ReactivityHuman, Monkey, Mouse, RatImmunogenSynthetic peptide corresponding to unique amino acid sequence on human CXCR7 protein.Accession #GenBank: AAH36661Physical PropertiesQuantity100 µgVolume200 µlConcentration0.68 µg/µl in antibody stabilization bufferFormAffinity PurifiedClonalityPolyclonalStorage-20⁰C for long term storageApplication ProtocolConfocal Microscopy1:250Immunocytochemistry1:250Immunofluorescence1:250Immunohistochemistry1:250Immunoprecipitation1:250Western Blot1:500ProteinUniprot #P25106OverviewAtypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CXCL11 and CXCL12/SDF1. Chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Molecular FunctionCell adhesion, Host-virus interactionSubcellular LocationCell membrane; Multi-pass membrane protein. Cytoplasm › perinuclear region. Early endosome. Recycling endosomeExpressionExpressed in monocytes, basophils, B-cells, umbilical vein endothelial cells (HUVEC) and B-lymphoblastoid cells. Lower expression detected in CD4+ T-lymphocytes and natural killer cells. In the brain, detected in endothelial cells and capillaries, and in mature neurons of the frontal cortex and hippocampus. Expressed in tubular formation in the kidney. Highly expressed in astroglial tumor endothelial, microglial and glioma cells. Expressed at low levels in normal CD34+ progenitor cells, but at very high levels in several myeloid malignant cell lines. Expressed in breast carcinomas but not in normal breast tissue.StructureHomodimer. Can form heterodimers with CXCR4; heterodimerization may regulate CXCR4 signaling activity. Interacts with ARRB1 and ARRB2.Alternative NomenclatureACKR3 antibodyatypical chemokine receptor 3 antibodyC X C chemokine receptor type 7 antibodyChemokine orphan receptor 1 antibodyCMKOR1 antibodyCXC R7 antibodyG protein coupled receptor 159 antibodyG protein coupled receptor RDC1 homolog antibodyGPR159 antibodyGPRN1 antibodyRDC 1 antibodyProtein information supplied by UniProt

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