产品说明
The GK1.5 monoclonal antibody reacts with the mouse CD4. The CD4 antigen is a 55 kDa cell surface type I membrane glycoprotein belonging to the immunoglobulin superfamily. CD4 acts as a co-receptor which in cooperation with the T cell receptor (TCR) interacts with class II MHC molecules displayed by antigen presenting cells (APC). CD4 is expressed by the majority of thymocytes, most helper T cells, a subset of NK-T cells and weakly by dendritic cells and macrophages. CD4 plays an important role in the development of T cells and is required for mature T cells to function optimally. The GK1.5 antibody has been shown to compete with clones YTS 177 and YTS 191 for CD4 binding.
Isotype
Rat IgG2b, κ
Recomended Isotype Control(s)
InVivoMAb rat IgG2b isotype control, anti-keyhole limpet hemocyanin
Recommended InVivoPure Dilution Buffer
InVivoPure pH 6.5 Dilution Buffer
Immunogen
Mouse CTL clone V4
Reported Applications
in vivo CD4+ T cell depletion
Flow cytometry
Western blot
Endotoxin
<2EU/mg (<0.002EU/μg)
Determined by LAL gel clotting assay
Purity
>95%
Determined by SDS-PAGE
Formulation
PBS, pH 6.5
Contains no stabilizers or preservatives
Sterility
0.2 μM filtered
Production
Purified from tissue culture supernatant in an animal free facility
Purification
Protein G
Storage
Undiluted at 4°C in the dark
References
SDS Sheet
Bio X Cell采用最先进的发酵技术;包括搅拌罐发酵罐和波包系统;我们的生产能力从5升到500升不等。
Bio X Cell提供从现有杂交瘤细胞系产生的抗体的生产和纯化服务。这些杂交瘤通常在客户的实验室中开发或在公共领域可用。
该服务包括在细胞培养物中发酵杂交瘤,通过离心收获细胞培养上清液以及通过30 kDa超滤浓缩。通过蛋白A或G亲和色谱进行纯化。将纯化的抗体透析到PBS中并过滤除菌。我们所有定制产品的内毒素水平<2EU / mg。我们还提供冻结细胞系,现场细胞系存储和MAP测试的额外费用。
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