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BioXcell/InVivoMAb anti-mouse CD103/REGULAR: 50MG/BE0026-R050mg
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产品说明
About InVivoMAb anti-mouse CD103The M290 monoclonal antibody reacts with mouse CD103 also known as integrin αE (ITGAE). CD103 is an integrin protein that binds integrin beta 7 to form the complete heterodimeric integrin molecule αEβ7. CD103 is expressed widely on intraepithelial lymphocyte (IEL) T cells (both αβ T cells and γδ T cells) and on some peripheral regulatory T cells. It has also been reported on lamina propria T cells. A subset of dendritic cells in the gut mucosa and in mesenteric lymph nodes also expresses CD103. The main ligand for CD103 is E-cadherin, an adhesion molecule expressed by epithelial cells. CD103 is thought to facilitate the interactions of T cells with epithelial cells during T cell maturation and effector functions. The M290 antibody is reported to neutralize CD103 in vivo.InVivoMAb anti-mouse CD103 SpecificationsIsotypeRat IgG2a, κRecommended Isotype Control(s)InVivoMAb rat IgG2a isotype control, anti-trinitrophenol(BE0089)Recommended InVivoPure Dilution BufferInVivoPure pH 7.0 Dilution Buffer(IP0070)ImmunogenMouse intestinal epithelial cellsReported Applicationsin vivo CD103 neutralizationImmunofluorescenceFlow cytometryEndotoxin<2EU/mg (<0.002EU/μg)Determined by LAL gel clotting assayPurity>95%Determined by SDS-PAGEFormulationPBS, pH 7.0Contains no stabilizers or preservativesSterility0.2 μM filteredProductionPurified from tissue culture supernatant in an animal free facilityPurificationProtein GStorageThe antibody solution should be stored at the stock concentration at 4°C. Do not freeze.RRIDAB_1107570Molecular Weight150 kDa
Bio X Cell采用最先进的发酵技术;包括搅拌罐发酵罐和波包系统;我们的生产能力从5升到500升不等。
Bio X Cell提供从现有杂交瘤细胞系产生的抗体的生产和纯化服务。这些杂交瘤通常在客户的实验室中开发或在公共领域可用。
该服务包括在细胞培养物中发酵杂交瘤,通过离心收获细胞培养上清液以及通过30 kDa超滤浓缩。通过蛋白A或G亲和色谱进行纯化。将纯化的抗体透析到PBS中并过滤除菌。我们所有定制产品的内毒素水平<2EU / mg。我们还提供冻结细胞系,现场细胞系存储和MAP测试的额外费用。
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