Product overview Name L-Quisqualic acid Short description AMPA receptor agonist / group I mGlu agonist Biological descriptionAMPA receptor agonist / group I mGlu agonist.Sensitizes neurons to excitatory amino acid analogues such as L-AP4, L-AP6 and L-AbetaH ("the Quis effect").Can act as an excitotoxin and is used to lesion areas of the brain in rat models. Biological action Agonist Purity >99% Our products in action Submit Your Citation NowProperties Chemical name (L)-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid Molecular Weight 189.13 Chemical structure Molecular Formula C5H7N3O5 CAS Number 52809-07-1Storing and Using Your Product Storage instructions room temperature Solubility overview soluble in NaOH(aq) (100mM, 1eq. NaOH) or water (10mM) Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.References for L-Quisqualic acidL-Quisqualic acid transport into hippocampal neurons by a cystine-sensitive carrier is required for the induction of quisqualate sensitization. Chase LA et al (2001) Neuroscience 106(2) : 287-301. PubMedID: 11566501 C-fos expression in the rat nucleus basalis upon excitotoxic lesion with quisqualic acid: a study in adult and aged animals. Giovannelli L et al (1998) J Neural Transm 105(8-9) : 935-48. PubMedID: 9869327 Prolonged nociceptive responses to hind paw formalin injection in rats with a spinal cord injury. Lee JW et al (2008) Neurosci Lett 439(2) : 212-5. PubMedID: 18524486 Effects of quisqualic acid analogs on metabotropic glutamate receptors coupled to phosphoinositide hydrolysis in rat hippocampus. Littman L et al (1995) Neuropharmacology 34(8) : 829-41. PubMedID: 8532164