ProductoverviewNameResiniferatoxinShortdescriptionPotentTRPV1channelagoNISTBIOLOGicaldescriptionCapsaicinanalogue.PotentTRPV1channelagonist(Ki=42.5pM).Showsactionsagainstneuropathicpainandinhibitsinflammatoryhyperalgesia.Showsmusculoskeletalhyperalgesiceffects.BiologicalactionAgonistPurity>98%OurproductsinactionSubmitYourCitationNowPropertiesChemicalname4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)-3a,3b,6,6a,9a,10,11,11a-octahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneacetateMolecularWeight628.72ChemicalstructureMolecularFormulaC37H40O9CASNumber57444-62-9StoringandUsingYourProductStorageinstructions-20°C(desiccate)SolubilityoverviewsolubleinDMSO(100mM)orethanol(50mM)ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.ReferencesforResiniferatoxinDistinctstructure-activityrelationsforstimulationof45Cauptakeandforhighaffinitybindinginculturedratdorsalrootganglionneuronsanddorsalrootganglionmembranes.AcsGetal(1996)BrainResMolBrainRes35(1-2):173-82.PubMedID:8717353Resiniferatoxin(RTX)causesauniquelyprotractedmusculoskeletalhyperalgesiainmicebyactivationofTRPV1receptors.ABDelhamidREetal(2013)JPain14(12):1629-41.PubMedID:24188863Perineuralresiniferatoxinselectivelyinhibitsinflammatoryhyperalgesia.NeubertJKetal(2008)MolPain4:3PubMedID:18199335
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。
热销产品线：
酶抑制剂和激动剂
ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。
离子通道调节剂
NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。
信号通路工具
各种信号通路抑制剂、激动剂
表观遗传学研究工具
potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等
受体配体
novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等
干细胞调节剂
ROCK inhibitor Y-27632, SB 431542 DAPT.
