ProductoverviewNameTamoxifenShortdescriptionEstrogenreceptorantagoNIST/partialagonistBIOLOGicaldescriptionEstrogenreceptorantagonistandalsopartialagonist.AlsopotentchloridechannelHSV-1inhibitor.Bloodbrainbarrierpermeable.Inhibitstumorgrowthandinducesapoptosisinbreastcancercells.Selectivelyinhibitssterolbiosynthesis(IC50=1000nM).Showsneuroprotectivepotential.BiologicalactionAntagonistPurity>99%OurproductsinactionSubmitYourCitationNowPropertiesChemicalname(Z)-2-[4-(1,2-Diphenyl-1-butenyl)phenoxy]-N,N-dimethylethanamineMolecularWeight371.52ChemicalstructureMolecularFormulaC26H29NOCASNumber10540-29-1PubChemidentifier2733526SMILESCC/C(=C(C1=CC=CC=C1)/C2=CC=C(C=C2)OCCN(C)C)/C3=CC=CC=C3InChiInChI=1S/C26H29NO/c1-4-25(21-11-7-5-8-12-21)26(22-13-9-6-10-14-22)23-15-17-24(18-16-23)28-20-19-27(2)3/h5-18H,4,19-20H2,1-3H3/b26-25-InChiKeyNKANXQFJJICGDU-QPLCGJKRSA-NMDLnumberMFCD00010454StoringandUsingYourProductStorageinstructionsRoomtemperatureSolubilityoverviewSolubleinDMSO(100mM)ImportantThisproductisforRESEARCHUSEONLYandisnotintendedfortherapeuticordiagnosticuse.Notforhumanorveterinaryuse.ReferencesforTamoxifenTamoxifeninhibitsinwardrectifierK+2.xfamilyofinwardrectifierchannelsbyinterferingwithphosphatidylinositol4,5-bisphosphate-channelinteractions.Ponce-BalbuenaDetal(2009)JPharmacolExpTher331(2):563-73.PubMedID:19654266BoththeimmunosuppressantSR31747andtheantiestrogentamoxifenbindtoanemopamil-insensitivesiteofmammalianDelta8-Delta7sterolisomerase.PaulRetal(1998)JPharmacolExpTher285(3):1296-302.PubMedID:9618436Growthinhibitionofestrogenreceptor-positiveandaromatase-positivehumanbreastcancercellsinmonolayerandspheroidculturesbyletrozole,anastrozole,andtamoxifen.KijimaIetal(2005)JSteroidBiochemMolBiol97(4):360-8.PubMedID:16263272Inhibitionofherpessimplexvirustype1entrybychloridechannelinhibitorstamoxifenandNPPB.ZhengKetal(2014)BiochemBiophysResCommun446(4):990-6.PubMedID:24657267
Hello Bio是由一群经验丰富的科学家和化学家们创立的充满活力的生物企业，总部位于英国布里斯托尔，在美国普林斯顿设有分公司，主旨在于提供质优价廉的生命科学研究工具，主要产品线为小分子化合物，如激动剂、拮抗剂、抑制剂等，部分产品价格甚至低至其他供应商的50%。
热销产品线：
酶抑制剂和激动剂
ROCK inhibitor Y-27632, PKA inhibitor KT 5720 , adenylyl cyclase activator Forskolin, and novel GRK2/3 inhibitor Cmpd101等。
离子通道调节剂
NMDA antagonist D-AP5, sodium channel blocker tetrodotoxin citrate, TRP antagonist capsazepine, and GABAA antagonist SR 95531 等。
信号通路工具
各种信号通路抑制剂、激动剂
表观遗传学研究工具
potent HDAC inhibitor Trichostatin A, DNA methyltransferase inhibitor 5-aza-2'-deoxycytidine,BET bromodomain inhibitor (+)-JQ1 and potent,selective GLP / G9a HMTase inhibitor BIX 01294 等
受体配体
novel selective GRK2/3 inhibitor, NMDA antagonist D-AP5, Group I mGlu agonist (S)-3,5-DHPG, and GABAA antagonist SR 95531.等
干细胞调节剂
ROCK inhibitor Y-27632, SB 431542 DAPT.
