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Abcam/Phorbol 12-myristate 13-acetate (PMA), PKC activator (ab120297)/1/PMA), PKC activator (ab120297
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产品说明
OverviewProduct namePhorbol 12-myristate 13-acetate (PMA), PKC activatorDescriptionPKC activatorAlternative namesPMABiological descriptionPotent nanomolar activator of protein kinase C in vivo and in vitro. Binds to C1 domain of protein kinase C, induces membrane translocation and enzyme activation. Also reported to have actions on non-kinase proteins including chimaerins, RasGRP and Unc-13/Munc-13. Extremely potent mouse skin tumor promoter.Purity>99%CAS Number16561-29-8Chemical structurePropertiesChemical namePhorbol 12-myristate 13-acetateMolecular weight616.83Molecular formulaC36H56O8PubChem identifier27924Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.Solubility overviewSoluble in DMSO to 100 mM and in ethanol to 10 mMHandlingThis product is supplied in one (or more) pack size which is freeze dried. Therefore the contents may not be readily visible, as they can coat the bottom or walls of the vial. Please see our FAQs and information page for more details on handling.Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.SMILESCC(=O)O[C@@]43[C@H](OC(=O)CCCCCCCCCCCCC)[C@@H](C)[C@@]1(O)[C@@H](C=C(CO)C[C@]2(O)C(=O)C(C)=C[C@@H]12)[C@@H]4C3(C)CSourceSyntheticResearch areasSignal TransductionProtein PhosphorylationSer / Thr KinasesPKCNeuroscienceNeurology processNeuroendocrinologyProlactinNeuroscienceNeurology processNeurodegenerative diseaseOtherCancerSignal transductionProtein phosphorylationSerine/threonine kinasesMAPK pathwayCardiovascularHeartHypertrophyOtherCancerCancer MetabolismMetabolic signaling pathwayMetabolism of lipids and lipoproteinsCancerCancer MetabolismResponse to hypoxiaBiochemicalsChemical TypeBiochemicalsBiochemicalsPharmacologyEnzymesKinaseProtein Kinase CActivatorsMetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipid metabolismMetabolismPathways and ProcessesMetabolism processesHypoxiaMetabolismTypes of diseaseObesity

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