产品说明
OverviewProduct nameCalyculin A, protein phosphatase inhibitorDescriptionPotent, selective and cell-permeable protein phosphatase inhibitorBiological descriptionPotent, selective and cell-permeable protein phosphatase inhibitor (IC50 values are 2 and 1 nM for PP1 and PP2A, respectively). Highly selective over PP2B and PP2C. Active in vivo and in vitro.Purity>99%CAS Number101932-71-2 Chemical structurePropertiesChemical name[(2R,3R,5R,7R,8S,9S)-2-[(1S,3S,4S,5R,6R,7E,9E,11E,13Z)-14-Cyano-3,5-dihydroxy-1-methoxy-4,6,8,9,13-pentamethyltetradeca-7,9,11,13-tetraenyl]-9-[(E)-3-[2-[(2S)-4-[[(2S,3S,4S)-4-(dimethylamino)-2,3-dihydroxy-5-methoxypentanoyl]amino]butan-2-yl]-1,3-oxazol-4-yl]prop-2-enyl]-7-hydroxy-4,4,8-trimethyl-1,10-dioxaspiro[4.5]decan-3-yl] dihydrogen phosphateMolecular weight1009.18Molecular formulaC50H81N4O15PPubChem identifier5311365Storage instructionsStore at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.Solubility overviewSoluble in ethanol and in DMSOHandlingWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.Toxic, refer to SDS for further information.Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.SMILESCC1C(CC2(C(C(C(O2)C(CC(C(C)C(C(C)C=C(C)C(=CC=CC(=CC#N)C)C)O)O)OC)OP(=O)(O)O)(C)C)OC1CC=CC3=COC(=N3)C(C)CCNC(=O)C(C(C(COC)N(C)C)O)O)OSourceDiscodermia calyxResearch areasCell BiologyCell CycleKinases/PhosphatasesPhosphatasesNeuroscienceNeurotransmissionIntracellular SignalingPhosphatasesSignal TransductionProtein PhosphorylationTyrosine PhosphatasesSignal TransductionProtein PhosphorylationSer / Thr PhosphatasesSignal TransductionMetabolismVitamins / MineralsCardiovascularAtherosclerosisDiabetes associatedCancerCancer MetabolismMetabolic signaling pathwayMetabolism of lipids and lipoproteinsBiochemicalsProduct RangeNewBiochemicalsChemical TypeBiochemicalsMetabolismPathways and ProcessesMetabolic signaling pathwaysLipid and lipoprotein metabolismLipid metabolismMetabolismPathways and ProcessesCofactors, Vitamins / mineralsVitamins / minerals
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