产品说明
OverviewProduct nameY-27632 dihydrochloride, Rho kinase inhibitorDescriptionSelective Rho kinase inhibitorBiological descriptionY-27632 is a research tool with a wide variety of biological effects, mainly used in the field of stem cell research for maintenance and differentiation.Commonly used as 3D growth matrix component; also a component of brain organoid differentiation media.How others have used Y-27632 in their research:Maintenance of tissue culture of iPSCs; 10 μM Y-27632 for 24 hr; Montefiori et al (2018)Reprogramming of breast cancer cells to induced progenitor-like cells (iPLs) ; 2 μM Y27632 ; Yuan et al (2018)Differentiation - Y-27632 enables human embryonic stem cells to survive and differentiate into cortical and basal telencephalic progenitors; Watanabe et al (2007)*Also available in simple stock solutions (ab144494) - add 1 ml of water to get an exact, ready-to-use concentration.Purity>99%CAS Number129830-38-2 Chemical structurePropertiesChemical name(R)-(+)-trans-4-(1-Aminoethyl)-N-(4-pyridyl)cyclohexanecarboxamide dihydrochlorideMolecular weight320.26Molecular formulaC14H21N3O.2HClPubChem identifier9901617Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.Solubility overviewSoluble in water to 100 mM and in DMSO to 100mMHandlingWherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.Refer to SDS for further information.Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.SMILESCl.Cl.O=C(Nc1ccncc1)[C@@H]2CC[C@H](CC2)[C@@H](C)NSourceSyntheticResearch areasCell BiologyApoptosisIntracellularKinasesSignal TransductionCytoskeleton / ECMCytoskeletonMicrofilamentsActin etcActin AssemblySignal TransductionProtein PhosphorylationSer / Thr KinasesOther KinasesSignal TransductionSignaling PathwayG Protein SignalingSmall G ProteinsRas FamilyCell BiologyCell CycleCell DivisionCentromereCancerCell cycleCell divisionCancerSignal transductionProtein phosphorylationSerine/threonine kinasesOtherBiochemicalsProduct RangeJust Add WaterBiochemicalsChemical TypeBiochemicalsBiochemicalsPharmacologyEnzymesKinaseRho kinaseInhibitorsBiochemicalsPharmacologySignalingExtracellular matrix & cell adhesionRho kinaseBiochemicalsPharmacologySignalingStem CellsOtherBiochemicalsResearch AreaCancerExtracellular matrix & cell adhesionRho kinase
Abcam超过1800种高质量的纯化二抗已在多种应用中得到验证，如蛋白质印迹，免疫组织化学，免疫细胞化学，ELISA和流式细胞仪。了解Abcam如何支持您的研究。
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