Description
PizotylineisastimulantthatactsasanantagoNISTat5-HT2Creceptorsandasapartialagonistat5-HT1Areceptors.Pizotylineisclinicallyusedtotreatmigraines,butalsoinhibitsdrug-inducedleverpressrespondingindrugdiscriminationmodels.
References
YoungR,KhoranaN,BondarevaT,etal.PizotylineeffectivelyattenuatesthestimuluseffectsofN-methyl-3,4-methylenedioxyamphetamine(MDMA).PharmacolBiochemBehav.2005Oct;82(2):404-10.PMID:16253319.
StrachanAT,LeiperJB,MaughanRJ.SEROtonin2CreceptorblockadeandThermoregulationduringexerciseintheheat.MedSciSportsExerc.2005Mar;37(3):389-94.PMID:15741836.
Newman-TancrediA,ConteC,ChaputC,etal.Agonistactivityofantimigrainedrugsatrecombinanthuman5-HT1Areceptors:potentialimplicationsforprophylacticandacutetherapy.NaunynSchmiedebergsArchPharmacol.1997Jun;355(6):682-8.PMID:9205951.