Description
HygromycinBisanantibioticthatalsodisplaysantiviralactivity.Hygromycinbindsthe30Sribosomalsubunit,inhibitingproteinandRNAsynthesisofbacteriaorviruses;itinducesmisreADIngsatmultiplestepsinproteintranslationandsuppressestranslocation.Inanimalmodels,hygromycinBallowstranslationtooccurbutpreventsformationofviralantigenbyLeishmaniaand,separately,preventsinfectionbymurinehepatitisvirus.
References
BrodersenDE,ClemonsWMJr,CarterAP,etal.Thestructuralbasisfortheactionoftheantibioticstetracycline,pactamycin,andhygromycinBonthe30Sribosomalsubunit.Cell.2000Dec22;103(7):1143-54.PMID:11163189.
RoYT,ScheffterSM,PattersonJL.HygromycinBresistancemediateseliminationofLeishmaniavirusfrompersistentlyinfectedparasites.JVirol.1997Dec;71(12):8991-8.PMID:9371555.
MacintyreG,WoodsDE,AndersonR.HygromycinBinhibitssynthesisofmurinecoronavirusRNA.AntimicrobAgentsChemother.1991Dec;35(12):2630-3.PMID:1667257.