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Discovery Antibodies/cis-ACBD/10 mg/A-281-10 mg
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Cat #: A-281 Alternative Name 1-Aminocyclobutane-1,3-dicarboxylic acidLyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.Bioassay Tested Bioassay TestedEvery lot is tried & tested in a relevant biological assay. Our BioassaySource SyntheticMW: 159.14Purity: >95%Form Lyophilized powder.Effective concentration 10-500 µM. Structure - + Chemical name 1-aminocyclobutane-1,3-dicarboxylic acid.Molecular formula C6H9NO4.CAS No.: 73550-55-7.Activity cis-ACBD is a weak NMDA receptor agonist1,2. References-Activity - + Allan, R.D. et al. (1990) J. Med. Chem. 33, 2905.Erreger, K. et al. (2007) Mol. Pharmacol. 72, 907.Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.Solubility 500 mM in H2O. Centrifuge all product preparations before use (10,000 x g for 1 min).Storage of solutions Up to four weeks at 4°C or three months at -20°C. Our bioassay - + Alomone Labs cis-ACBD activates NMDA receptors (NR1+NR2A) expressed in Xenopus oocytes. Time course of NMDA receptor current activation by 1 to 500 μM cis-ACBD (#A-281) (at -80 mV). Amplitude change as a result of the application of rising concentrations of cis-ACBD (perfusion duration indicated by the horizontal bar, concentration as indicated). References - Scientific background1. Fletcher, E.J. et al. (1991) Neurosci. Lett. 121, 133.2. Allan, R.D. et al. (1990) J. Med. Chem. 33, 2905.3. Talukder, I. et al. (2010) J. Neurosci. 30, 11792. Scientific background - + trans-ACBD is a potent, competitive and selective activator of glutamate uptake. The compound acts as an NMDA (N-methyl-D-aspartate) receptor agonist. The ACBD structure includes two isomers: cis-1-aminocyclobutane-1,3-dicarboxylic acid and trans-1-aminocyclobutane-1,3-dicarboxylic acid. Several studies have shown that the trans isomer is more potent than the cis isomer. The trans isomer was also shown to be 20 times more active than NMDA1,2, the major excitatory neurotransmitter in the mammalian central nervous system (CNS).Several studies suggest that modifications and changes of glutamate uptake could play a role in processes underlying synaptic plasticity in the CNS2.NMDA receptors are ion channels gated by glutamate. Glutamate-mediated signaling is important for basic neuron-neuron signaling and neuronal processes such as learning, memory and pain perception3.Target NMDA receptorsLyophilized PowderClick here to receive a 5 mg free trial sample! Certificate of AnalysisLast update: 24/09/2019cis-ACBD (#A-281) is a highly pure, synthetic, and biologically active compound.For research purposes only, not for human use

Discovery®抗体是剑桥生物化学研究所(CRB)的新目录抗体业务。



CRB是世界上第二大多肽公司,也是抗体研究市场的领跑者,从目录业务到现在已有22年的休息期(1994-2016年),现在是第37年(2017年),CRB推出了一个全新的现成抗体业务,名为Discovery®抗体。



Discovery®抗体将专注于研究抗体(早期药物“Discovery”),并将补充我们非常成功和长期的定制抗体业务(www.crbdiscovery.com网站). 我们以新颖、复杂、稀有和翻译后修饰的特异性抗体而闻名,这些备受追捧的目标将出现在我们的发现®抗体目录范围内。



我们于2017年2月推出了我们的发现®抗体,一年后发现®肽,大约240年后,詹姆斯·库克船长(他那个时代最伟大的探险家)于1776年从英国乘“发现”号船出发,包租全球的新水域和“发现”新大陆。因此,“发现”这个名字似乎适合东北部的一家制造商——詹姆斯·库克的家乡。



在17世纪末对世界各地新发现的土地的探索和2000年医学研究的新“发现”以及人类基因组的绘制之间产生了进一步的相似之处。



有关更多详情,请参阅我们发布的Discovery®抗体的新闻稿



剑桥研究生物化学(www.crbdiscovery.com网站)是一家领先的定制肽和抗体工具的独立生产商,为全球制药、生命科学和学术领域的研究人员提供服务。其产品的主要用途是作为定制的实验室级试剂,用于证明早期药物发现中的主要研究,并支持临床研究中的生物标记物方案。该公司生产各种口味的肽,从简单到改性,稳定,从毫克到克标到最高纯度的染料标签。

Discovery®抗体是剑桥生物化学研究所(CRB)的新抗体目录业务

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