首页 > Discovery > Discovery Antibodies/(S)(-)-Bay K8644/50 mg/B-351-50 mg

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Discovery Antibodies/(S)(-)-Bay K8644/50 mg/B-351-50 mg

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B-351-50mg

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Discovery

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Cat #: B-351 Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.Bioassay Tested Bioassay TestedEvery lot is tried & tested in a relevant biological assay. Our BioassaySource SyntheticMW: 356.3Purity: >98% (HPLC)Form Lyophilized powder.Effective concentration 50 nM - 5 µM. Structure - + Chemical name (4S)-1,4-dihydro-2,6-dimethyl-5-nitro-4-[2-trifluoromethyl)phenyl]-3-pyridinecarboxylic acid methyl ester.Molecular formula C16H15 F3N2O4.CAS No.: 98625-26-4.Activity (S)(-)-Bay K8644 is an L-type Ca2+-channel activator. It displays vasoconstrictive effects in vivo1. References-Activity - + Franckowiak, G. et al. (1985) Eur. J. Pharmacol. 114, 223.Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.Solubility 100 mM in DMSO. Centrifuge all product preparations before use (10000 x g for 1 min).Storage of solutions Up to four weeks at 4°C or three months at -20°C. Our bioassay - + Alomone Labs (S)(-)-Bay K8644 increases L-type CaV channel currents heterologously expressed in Xenopus oocytes.A. Time course of CaV1.2 (co-expressed with α2δ1 and β1 auxiliary subunits) peak current amplitude, elicited by 100 ms voltage ramp from holding potential of -100 mV to +50 mV, delivered every 10 seconds. Application of 0.1 and 1 µM (S)(-)-Bay K8644 (#B-351) increases the CaV1.2 current (indicated by the horizontal bar). B. Representative current traces before and during application of 0.1 and 1 µM (S)(-)-Bay K8644 as indicated. References - Scientific background1. Hadley, R.W. and Hume, J.R. (1988) Circ. Res. 62, 97.2. Wei, X.Y. et al. (1986) J. Pharmacol. Exp. Ther. 239, 144. Scientific background - + (S)(-)-Bay K8644 is an L-type Ca2+-channel activator with positive inotropic, vasoconstrictive and behavioral effects in vivo. It is an enantiomer of (±)-Bay K8644. (S)(-)-Bay K8644 is a dihydropyridine that can, among other effects, constrict blood vessels and increase the force of contraction of the heart. The drug is thought to increase the entry of Ca2+ into cells by increasing the open-state probability of Ca2+ channels, either by prolonging the duration of individual openings or by increasing the number of openings. It was noted in early experiments with Bay K8644 that the dose-response curve is biphasic1. The action of (S)(-)-Bay K8644 was studied in rat tail artery and guinea pig ileal longitudinal smooth muscle using pharmacologic and radioligand binding assays. It induced concentration-dependent contractions in both smooth muscle preparations with EC50 values of 1.98-11 nM. With increasing concentrations, (S)(-)-Bay K8644 relaxed the tissue with IC50 values of 0.53-2.60 μM2.Target L-type Ca2+ channelsLyophilized PowderClick here to receive a 1 mg free trial sample! Certificate of AnalysisLast update: 24/09/2019(S)(-)-Bay K8644 (#B-351) is a highly pure, synthetic, and biologically active compound.For research purposes only, not for human use

Discovery®抗体是剑桥生物化学研究所（CRB）的新目录抗体业务。

CRB是世界上第二大多肽公司，也是抗体研究市场的领跑者，从目录业务到现在已有22年的休息期（1994-2016年），现在是第37年（2017年），CRB推出了一个全新的现成抗体业务，名为Discovery®抗体。

Discovery®抗体将专注于研究抗体（早期药物“Discovery”），并将补充我们非常成功和长期的定制抗体业务(www.crbdiscovery.com网站). 我们以新颖、复杂、稀有和翻译后修饰的特异性抗体而闻名，这些备受追捧的目标将出现在我们的发现®抗体目录范围内。

我们于2017年2月推出了我们的发现®抗体，一年后发现®肽，大约240年后，詹姆斯·库克船长（他那个时代最伟大的探险家）于1776年从英国乘“发现”号船出发，包租全球的新水域和“发现”新大陆。因此，“发现”这个名字似乎适合东北部的一家制造商——詹姆斯·库克的家乡。

在17世纪末对世界各地新发现的土地的探索和2000年医学研究的新“发现”以及人类基因组的绘制之间产生了进一步的相似之处。

有关更多详情，请参阅我们发布的Discovery®抗体的新闻稿

剑桥研究生物化学(www.crbdiscovery.com网站)是一家领先的定制肽和抗体工具的独立生产商，为全球制药、生命科学和学术领域的研究人员提供服务。其产品的主要用途是作为定制的实验室级试剂，用于证明早期药物发现中的主要研究，并支持临床研究中的生物标记物方案。该公司生产各种口味的肽，从简单到改性，稳定，从毫克到克标到最高纯度的染料标签。

Discovery®抗体是剑桥生物化学研究所（CRB）的新抗体目录业务