首页 > Discovery > Discovery Antibodies/Amitriptyline hydrochloride/100 g/A-155-100 g

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Discovery Antibodies/Amitriptyline hydrochloride/100 g/A-155-100 g

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A-155-100g

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Discovery

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Cat #: A-155 Alternative Name Annoyltin®, Tryptizol®, Domical®, Elavil hydrochloride®, Amavil®, Saroten®, Ami-Anelun®, Lentizol®Lyophilized Powder Lyophilized PowderThis product is freeze dried. All water molecules have been removed.Bioassay Tested Bioassay TestedEvery lot is tried & tested in a relevant biological assay. Our BioassaySource SyntheticMW: 313.86Purity: >99%Effective concentration 1-100 µM. Structure - + Chemical name 3-(10,11-Dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine hydrochloride.Molecular formula C20H24ClN.CAS No.: 549-18-8.Activity Inhibitor of serotonin and noradrenalin uptake. Also activates α2A-adrenoceptors and antagonizes 5-HT2 receptors. Displays antinociceptive activity1. References-Activity - + Wu, W. et al. (2012) Neurosci. Lett. 506, 307.Shipping and storage Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.Solubility DMSO. Centrifuge all product preparations before use (10000 x g 5 min).Storage of solutions Up to four weeks at 4°C or three months at -20°C. Our bioassay - + Alomone Labs Amitriptyline hydrochloride inhibits L-type voltage-gated Ca2+ currents expressed in Xenopus oocytes.A. Time course of CaV1.2/α2-δ1/β1 current inhibition by 800 µM Amitriptyline hydrochloride (#A-155). Currents were elicited by application of voltage ramps from a holding potential of -100 mV to +50 mV (100 msec). B. Superimposed example traces of current responses before and during perfusion of 800 µM Amitriptyline hydrochloride, as indicated. References - Scientific background1. Soldatov, N.M. (2012) ISRN Mol. Biol. 2012, 691341.2. Haderer, A. et al. (2003) Anesth. Analg. 96, 1707.3. Baldessarini, R.J. et al. (1995) The Pharmacological Basis of Therapeutics 431.4. Bryson, H.M. and Wilde, M.I. (1996) Drugs Aging 8, 459.5. Zahradník, I. et al. (2008) J. Pharmacol. Exp. Ther. 324, 977. Scientific background - + Voltage-gated L-type CaV1.2 calcium channels couple membrane depolarization to transient increase in cytoplasmic free Ca2+ concentration that initiates a number of essential cellular functions including cardiac and vascular muscle contraction, gene expression, neuronal plasticity, and exocytosis1.Tricyclic antidepressants (TCAs) are known to inhibit Ca2+ currents, including the L-type CaV1.2 channel in heart myocyte and neurons2. Other known physiological targets of tricyclic antidepressants in the central nervous system are the 5-HT2 serotonin receptors and the α1-adrenergic receptors3.Amitriptyline hydrochloride, a tricyclic antidepressant, is used for a number of medical conditions including management of depressive, anxiety and bipolar disorders3 and management of chronic pain such as neuropathic pain, diabetic neuropathy, postherpetic neuralgia and fibromyalgia4.The proposed mechanisms of action for amitriptyline hydrochloride include inhibition of the reuptake of serotonin and norepinephrine, inhibition of NMDA receptors, of voltage-gated ion channels such as Ca2+ and Na+ channels and interaction with adenosine receptors5.Target L-type Ca2+ channels, α-adrenergic receptors, 5-HT2 serotonin receptorsLyophilized PowderClick here to receive a 10 g free trial sample! Certificate of Analysis SDSLast update: 22/09/2019Amitriptyline hydrochloride (#A-155) is a highly pure, synthetic, and biologically active compound.For research purposes only, not for human use

Discovery®抗体是剑桥生物化学研究所（CRB）的新目录抗体业务。

CRB是世界上第二大多肽公司，也是抗体研究市场的领跑者，从目录业务到现在已有22年的休息期（1994-2016年），现在是第37年（2017年），CRB推出了一个全新的现成抗体业务，名为Discovery®抗体。

Discovery®抗体将专注于研究抗体（早期药物“Discovery”），并将补充我们非常成功和长期的定制抗体业务(www.crbdiscovery.com网站). 我们以新颖、复杂、稀有和翻译后修饰的特异性抗体而闻名，这些备受追捧的目标将出现在我们的发现®抗体目录范围内。

我们于2017年2月推出了我们的发现®抗体，一年后发现®肽，大约240年后，詹姆斯·库克船长（他那个时代最伟大的探险家）于1776年从英国乘“发现”号船出发，包租全球的新水域和“发现”新大陆。因此，“发现”这个名字似乎适合东北部的一家制造商——詹姆斯·库克的家乡。

在17世纪末对世界各地新发现的土地的探索和2000年医学研究的新“发现”以及人类基因组的绘制之间产生了进一步的相似之处。

有关更多详情，请参阅我们发布的Discovery®抗体的新闻稿

剑桥研究生物化学(www.crbdiscovery.com网站)是一家领先的定制肽和抗体工具的独立生产商，为全球制药、生命科学和学术领域的研究人员提供服务。其产品的主要用途是作为定制的实验室级试剂，用于证明早期药物发现中的主要研究，并支持临床研究中的生物标记物方案。该公司生产各种口味的肽，从简单到改性，稳定，从毫克到克标到最高纯度的染料标签。

Discovery®抗体是剑桥生物化学研究所（CRB）的新抗体目录业务