首页 > Biosensis > Biosensis/Mouse monoclonal antibody to alpha Synuclein [3H9]/M-1402-100/100 µg

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Biosensis/Mouse monoclonal antibody to alpha Synuclein [3H9]/M-1402-100/100 µg

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M-1402-100

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4000-520-616

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DescriptionAlphasynucleinisanabundant140aminoacidneuronalprotein,expressedprimarilyatpresynapticterminalsinthecentralnervoussystem.FUNCTION:Maybeinvolvedintheregulationofdopaminereleaseandtransport.Solubleprotein,normallylocalizedprimarilyatthepresynapticregionofaxons,whichcanformfilamentousaggregatesthatarethemajornonamyloidcomponentofintracellularinclusionsinseveralneurodegenerativediseases(synucleinopathies).Inducesfibrillizationofmicrotubule-associatedproteintau.Reducesneuronalresponsivenesstovariousapoptoticstimuli,leADIngtoadecreasedcaspase3activation.TISSUESPECIFICITY:Expressedprincipallyinbrainbutisalsoexpressedinlowconcentrationsinalltissuesexaminedexceptinliver.Concentratedinpresynapticnerveterminals.SUBUNIT:Solublemonomerwhichcanformfilamentousaggregates.InteractswithUCHL1.InteractswithphospholipaseDandhistones.SUBCELLULARLOCATION:Cytoplasm.Membrane.Nucleus.Note=Membrane-boundindopaminergicneurons.Alsofoundinthenucleus.ALTERNATIVEPRODUCTS:3namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.BatchNo.SeeproductlabelUnitsize100µgAntigenRecombinantfulllengthhumanalphasynucleinexpressedandpurifiedfromE.coliAntigenLocationMultiplesubcellularlocationsreportedaswellassecretedextracellularlyincertainconditions.AntibodyTypeMonoclonalIsotypeIgG1Clone3H9OtherNamesNon-AbetacomponentofADamyloid;Non-A4componentofamyloidprecursor;NACPAccessionP37840SYUA_HUMAN;ProducedinMouseMolecularWeight14-15kDa,reducedPAGEpreparationsPurityProteinGpurifiedmouseIgGApplicationsWesternBlotting(WB)andImmunocytochemistry(IC/IF).Adilutionof1:1,000-1:5,000isrecommendedforWB.Adilutionof1:500-3,000isrecommendedforIC/IF.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThespecificityofthisantibodyhasbeenconfirmedbyWB.Thisantibodydetects~14-15kDaalphasynucleinprotein.Theepitopefor3H9isintheregion61-95whichcorrespondtotheNon-AmyloidbetaComponentofAlzheimersdiseaseamyloid(NAC)region.3H9willalsobindhumanalpha-synucleincontainingtheA30PandA53Tmutations.Cross-reactivityHuman,horse,cow,pig,chicken,rat,mouse.Predictedtoreactwithothermammaliantissuebecauseofhighlyconservednatureoftheprotein.BlastURLClickhereFormLyophilized,fromPBSwith5%trehaloseand0.05%sodiumazide.AppearanceWhitepowderReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.Finalbuffercontains0.05%sodiumazideasapreservativeStorageAfterreconstitutionoflyophilizedantibody,divideintosingleusealiquotsandstoreat-20-80°CforahigherstABIlity.Avoidfreeze-thawcycles.ExpiryDate12monthsafterpurchaseMSDSMSDS_M-1402-100_as_at_July2015.pdf

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。