首页 > Biosensis > Biosensis/Rabbit polyclonal antibody to human Insulin receptor subunit alpha (59-75): Affinity purified/R-1124-100/100 µg

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Biosensis/Rabbit polyclonal antibody to human Insulin receptor subunit alpha (59-75): Affinity purified/R-1124-100/100 µg

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R-1124-100

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DescriptionTheInsulinreceptorbindsinsulinandhasatyrosine-proteinkinaseactivity.Thereceptorisatetramerof2alphaand2betasubunitslinkedbydisulfidebonds.Thealphasubunit(135kDa)isextracellularandcontributestotheformationoftheligand-bindingdomainwhereasthebetasubunit(95kDa)containsthekinasedomainandatransmembranedomain.AtleasttwoisoformsoftheInsulinreceptorareproducedbyalternativesplicing.BatchNo.SeeproductlabelUnitsize100µgAntigenAsyntheticpeptide(HLQILLMFKTRPEDFRD)correspondingtoaregion(59-75)fromhumanInsulinreceptor(isoformLong).Toenhancetheimmunologicalresponse,thispeptidewascoupledtocarrierproteinBSA.OtherNamesIR;EC2.7.10.1;CD220;INSR;AccessionP06213INSR_HUMAN;ProducedinRabbitPurityAffinitypurifiedonantigencolumnApplicationsImmunohistochemistry(IHC)andWesternBlotting(WB).Aconcentrationof0.1-0.5µg/mlisrecommendedforWB.HumanInsulinreceptor(isoformLong)hasapredictedlengthof1382aminoacidsandMWof156kDa.Aconcentrationof0.5-1.0µg/mlisrecommendedtodetecttheproteininformalinfixedandparaffinembeddedtissues.Boilingtheparaffinsectionsin10mMcitratebuffer,pH6.0for20minutesisrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThespecificityofthisantibodyhasbeenconfirmedbyWBandIHCagainsttheantigen.Cross-reactivityHuman;dog;rat;predictedtoreactwithmouseduetosequencehomology;BlastitIfyouwishtousethisproductinaspeciesotherthanthosespecifiedhereandwanttodeterminetheaminoacidsequencehomologybetweentheimmunogenandthecorrespondingproteininthatspecies,simplycopytheaminoacidsequenceforthisimmunogenandtestitontheBLASTdatabasethatyoucanaccessthroughthelinkbelow.Pleasenotethatantibodiesraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptide.Whatthismeansinpractiseisthatasingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.TheBLASTdatabasecanalsobeusedtocompareanyaminoacidsequencebetweenspeciesandbetweenprotein.ThefullaminoacidsequenceofthetargetproteincanbefoundbyfollowingthelinkintheAccessionfield.YoucanthensearchanyaminoacidsequenceinthetargetproteinusingtheBLASTdatabase.Whenselectingasequencetosearch,pleasechoosecarefully,asthesequenceyouchoosemaybeaprecursorratherthanthematureproteinforexample.FormLyophilisedwith5mgBSA,0.9mgNaCl,0.2mgNa2HPO4,0.05mgThimerosal,0.05mgNaN3ReconstitutionReconstitutein100µlofsteriledistilledwatertoachieveanantibodyconcentrationof1mg/ml.Centrifugetoremoveanyinsolublematerial.StorageAtleast12monthsafterpurchaseat2-4°C(lyophilizedformulations).Afterreconstitution,aliquotandstoreat-20°CforahigherstABIlityforupto6months.Avoidfreeze-thawcycles.ExpiryDate12monthsafterpurchaseunopened

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。