首页 > Biosensis > Biosensis/Mouse monoclonal antibody to DJ-1 [PARK7]: IgG/M-1573-100/100 µg

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Biosensis/Mouse monoclonal antibody to DJ-1 [PARK7]: IgG/M-1573-100/100 µg

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M-1573-100

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4000-520-616

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DescriptionProteinDJ-1hasmanyrolesincludingprotectingcellsagainstoxidativestressandcelldeath(Ref:SwissProt).MutationsintheDJ-1genehavebeenassociatedwithrareformsofautosomalrecessiveearly-onsetParkinson"sdisease.BatchNo.SeeproductlabelUnitsize100µgAntigenFulllengthrecombinanthumanDJ-1expressedinandpurifiedfromE.coli.AntibodyTypemonoclonalIsotypeIgG1/kappaClone4H4OtherNamesOncogeneDJ1;Parkinsondiseaseprotein7;PARK7;DJ-1AccessionQ99497PARK7_HUMAN;ProducedinMouseApplicationsWB,IHC/IF.Suggesteddilutionofatleast1:1,000forIHC/IF.Dilutionsof1:10,000orlowerisrecommendedforWB.Thisantibodyrevealsaprominent~21kDabandandstainsmainlyincytoplasmoftissueculturecells.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityTheantibodyreactswitha21kDabandbyWesternblotonwholeHeLacelllysate.Ithasalsobeenusedsuccessfullyforimmunocytochemistry.SpeciesAgainstHuman,Mouse,BovineAntibodyAgainstDJ1[PARK7]BlastURLClickhereFormLyophilizedfromPBS.Contains5%trehalose.AppearanceWhitepowderReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.ExpiryDate12monthsafterpurchaseGeneralReferences1.NagakuboD,TairaT,KitauraH,IkedaM,TamaiK,Iguchi-ArigaSMandArigaHDJ-1,anoveloncogenewhichtransformsmouseNIH3T3cellsincooperationwithras.Biochem.Biophys.Res.Commun.231,509513(1997).2.BonifatiV,RizzuP,vanBaren,M.J.,SchaapO,BreedveldGJ,KriegerE,DekkerMC,SquitieriF,IbanezP,JoosseMetal.MutationsintheDJ-1geneassociatedwithautosomalrecessiveearly-onsetParkinsonism.Science,299,256259(2003).3.XuJ,ZhongN,WangH,EliasJE,KimCY,WoldmanI,PiflC,GygiSP,GeulaC,YanknerBA.TheParkinson"sdisease-associatedDJ-1proteinisatranscriptionalco-activatorthatprotectsagainstneuronalapoptosis.HumMolGenet.14(9):1231-41(2005).4.YokotaT,SugawaraK,ItoK,TakahashiR,ArigaH.AndMizusawa,H.DownregulationofDJ-1enhancescelldeathbyoxidativestress,ERstress,andproteasomeinhibition.Biochem.Biophys.Res.Commun.,312,13421348(2003).5.TairaT,SaitoY,NikiT,Iguchi-ArigaSM,TakahashiKandArigaH.DJ-1hasaroleinantioxidativestresstopreventcelldeath.EMBORep.,5,213218(2004).6.BonifatiV,OostraBA.andHeutink,P.LinkingDJ-1toneurodegenerationoffersnovelinsightsforunderstandingthepathogenesisofParkinsonsdisease.J.Mol,Med.82,163-174(2004).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。