首页 > Biosensis > Biosensis/Mouse monoclonal antibody to Microtubule-associated protein tau/M-1703-100/100 uL

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Biosensis/Mouse monoclonal antibody to Microtubule-associated protein tau/M-1703-100/100 uL

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M-1703-100

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DescriptionFUNCTION:PromotesmicrotubuleassemblyandstABIlity,andmightbeinvolvedintheestablishmentandmaintenanceofneuronalpolarity.TheC-terminusbindsaxonalmicrotubuleswhiletheN-terminusbindsneuralplasmamembranecomponents,suggestingthattaufunctionsasalinkerproteinbetweenboth.Axonalpolarityispredeterminedbytaulocalization(intheneuronalcell)inthedomainofthecellbodydefinedbythecentrosome.TheshortisoformsallowplasticityoftheCytoskeletonwhereasthelongerisoformsmaypreferentiallyplayaroleinitsstabilization. SUBCELLULARLOCATION:Cytoplasm;cytosol.Cellmembrane.Mostlyfoundintheaxonsofneurons,inthecytosolandinassociationwithplasmamembranecomponents.ALTERNATIVEPRODUCTS:8namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.Isoformsdifferfromeachotherbythepresenceorabsenceofupto5ofthe15exons.Oneoftheseoptionalexonscontainstheadditionaltau/MAPrepeat.TISSUESPECIFICITY:Expressedinneurons.IsoformPNS-tauisexpressedintheperipheralnervoussystemwhiletheothersareexpressedinthecentralnervoussystem.DEVELOPMENTALSTAGE:Four-repeat(typeII)tauisexpressedinanadult-specificmannerandisnotfoundinfetalbrain,whereasthree-repeat(typeI)tauisfoundinbothadultandfetalbrain.DOMAIN:Thetau/MAPrepeatbindstotubulin.InAlzheimerdisease,theneuronalcytoskeletoninthebrainisprogressivelydisruptedandreplacedbytanglesofpairedhelicalfilaments andstraightfilaments,mainlycomposedofhyperphosphorylatedformsofMicrotubule-associatedproteinTau.DefectsinMicrotubule-associatedproteinTauareacauseoffrontotemporaldementiaandparkinsonismlinkedtochromosome17,aswellasanumberofotherneurodegenerativediseases.BatchNo.SeeviallabelUnitsize100uLAntigenRecombinantfulllengthversionoftheshortesthumantauisoformpurifiedfromE.coli.AntibodyTypeMonoclonalIsotypeIgG1OtherNamesNeurofibrillarytangleprotein;Pairedhelicalfilament-tau;PHF-tau;MAPT;MTBT1;TAUProducedinMouseApplicationsWesternBlotting(WB)andImmunocytochemistry(ICC).Adilutionof1:5,000-1:10,000isrecommendedforWB.Adilutionof1:500-1,000isrecommendedforICC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityTheantibodyreactswithmultiplecloselyspacedbandscoveringtheregionoftheblotfrom48kDato67kDa.Ithasalsobeenusedsuccessfullyforimmunocytochemistry.SpeciesAgainstHuman,ratandmouse.Itisexpectedthatitwillworkonothermammaltissues.FormLyophilisedpurifiedculturesupernatantwith5%trehaloseand0.5%sodiumazide.AppearanceWhitepowderReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.StorageMaintainlyophilizedmaterialat2-8°C.Afterreconstitutionoflyophilizedantibody,aliquotandstoreat-20°Cforahigherstability.Avoidfreeze-thawcycles.ExpiryDate12monthsafterpurchaseGeneralReferences1.SkeneJH,WillardM.Changesinaxonallytransportedproteinsduringaxonregenerationintoadretinalganglioncells.J.CellBiol.89:86-95(1981).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。