首页 > Biosensis > Biosensis/Mouse monoclonal antibody to Ubiquitin [Ubi-1]/M-1404-100/100 µl

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Biosensis/Mouse monoclonal antibody to Ubiquitin [Ubi-1]/M-1404-100/100 µl

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DescriptionUbiquitinisahighlyconserved76aminoacidproteinwithanestimatedmolecularweightof8.56kDawhichhasacentralroleinregulatedproteindegradation.Itisaproteinmodifierwhichcanbecovalentlyattachedtotargetlysineseitherasamonomerorasalysine-linkedpolymer.Severaltypesofpolymericchainscanbeformeddependingonthelysineusedfortheassembly.Attachmenttoproteinsasapolymerleadstotheirdegradationbythe26Sproteosome;acomplex,multicatalyticcytosolicandnuclearprotease.Attachmenttoproteinsasamonomerorasanalternativelylinkedpolymerdoesnotleadtoproteasomaldegradationandmayberequiredfornumerousfunctions,includingmaintenanceofchromaticstructure,regulationofgeneexpression,stressresponse,ribosomebiogenesisandDNArepair.Ubiquitinissynthesizedasapolyubiquitinprecursorwithexactheadtotailrepeats,thenumberofrepeatsofwhichdifferbetweenspeciesandstrains.Insomespeciesthereisafinalamino-acidafterthelastrepeat,hereinbovineaCys.Someubiquitingenescontainasinglecopyofubiquitinfusedtoaribosomalprotein(eitherL40orS27a).BatchNo.SeeproductlabelUnitsize100µlAntigenRaisedagainstpurifiedubiquitinconjugatedwithglutaraldehydetokeyholelimpethemocyanin.AntibodyTypeMonoclonalIsotypeIgG1CloneUbi-1OtherNamesRPS27A;UBA52;UBB;UBC;Polyubiquitin-B;Polyubiquitin-C;AccessionP0CG47UBB_HUMAN;ProducedinMouseApplicationsWesternBlotting(WB),Immunohistochemistry-paraffinembeddedtissue(IH-P)andELISA.SuggesteddilutionforWBis1:500-1,000.ThisantibodycanbeusedonmildlyfixedhistologicalsectionsofhumanbrainforstudiesofAlzheimer'sdisease.Thisantibodyalsoworksonparaffinembeddedmaterial.ItalsorecognisesotherubiquinatedinclusionbodiessuchasLewybodiesofParkinson'sdiseaseandthePickbodiesinPick'sdiseaseinformalinfixedtissues.SuggesteddilutionforIHis1:500.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThespecificityofthisantibodyhasbeenconfirmedbyWB.Thisantibodydetects~8.5kDaUbiquitin.AntibodyAgainstUbiquitinCross-reactivityHu,Bov,Chk,Drosophila,andC.elegansBlastURLClickhereFormLyophilisedwith5%trehaloseAppearanceWhitepowderReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.ExpiryDate12monthsafterpurchaseSpecificReferences1.JosephsK.A.etal(2006)Atypicalprogressivesupranuclearpalsywithcorticospinaltractdegeneration.JNeuropatholExpNeurol.2006Apr;65(4):396-405.2.JosephsK.A.etal(2007)Neuropathologicfeaturesoffrontotemporallobardegenerationwithubiquitin-positiveinclusionswithprogranulingene(PGRN)mutations.JNeuropatholExpNeurol.2007Feb;66(2):142-51.3.RudzinskiL.A.etal(2008)EarlyonsetfamilialAlzheimerDiseasewithspasticparaparesis,dysarthria,andseizuresandN135SmutationinPSEN1.AlzheimerDisAssocDisord.2008Jul-Sep;22(3):299-307.4.JosephsK.A.etal(2009)EvaluationofsubcorticalpathologyandclinicalcorrelationsinFTLD-Usubtypes.ActaNeuropathol.2009Sep;118(3):349-58.

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。