首页 > Biosensis > Biosensis/Mouse monoclonal antibody to Visinin-like protein 1/M-1657-100/1 Ea

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Biosensis/Mouse monoclonal antibody to Visinin-like protein 1/M-1657-100/1 Ea

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Description Visinin(sometimesknownashippocalcin-likeprotein3,HLP3,HPCAL3,HUVISL1,VLP-1,VILIPandVILIP-1)wasoriginallyisolatedbiochemicallyfromchickenretinaasamajorproteinofabout24kDaonSDS-PAGE(1).Followingcloningandsequencingofvisinin,severalvisininlikeproteinswerediscoveredbyhomologyscreening(2,3).Oneofthese,Visinin-likeprotein1isasmallCalciumbindingproteinwhichisveryabundantinthenervoussystemandisfoundonlyinneurons,thoughdifferentneuronshavedifferentlevelsofexpression(4,5).ItisparticularlyconcentratedincerebellarPurkinjecells,andtendstobemostabundantinperikaryaanddendrites.TheproteinbelongstothelargesuperfamlyofcalmodulinandparavalbumintypeproteinswhichfunctionbybindingCalciumions.Calciumbindingalterstheconfomationoftheseproteinsandallowthemtointeractwithotherbindingpartners,thepropertiesofwhichtheymayalter.Visinin-likeprotein1hasfour"EFhand"domains,whicharenegativelychargedhelix-turn-helixpeptideswhichareresponsIBLeforCalciumbinding.Visinin-likeprotein1is191aminoacidsinsizeandhasamolecularweightonSDS-PAGEof22kDa.TheproteinhasrecentlybeensuggestedtobeausefulbioMarkerofAlzheimer"sdiseaseandtraumaticbraininjury(6,7,8).AntigenRecombinantVisinin-likeprotein1expressedandpurifiedfromE.coli.AntibodyTypeMonoclonalIsotypeIgG1OtherNamesHippocalcin-likeprotein3,HLP3,HPCAL3,HUVISL1,VLP-1,VILIPandVILIP-1ProducedinMouseApplicationsWesternBlotting(WB)andImmunocytochemistry(IC).Adilutionof1:1,000-1:2,000isrecommendedforWB.Adilutionof1:500-1:1,000isrecommendedforIC.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityTheantibodyreactswitha22kDabandbyWesternblotonbovinecerebellumlysate.Ithasalsobeenusedsuccessfullyforimmunocytochemistry.SpeciesAgainstHuman,bovine,ratandmouse.Itisexpectedthatitwillworkonothermammaltissues.AntibodyAgainstVisinin-likeprotein1FormLyophilisedfromPBS.Contains5%trehalose.AppearanceWhitepowderReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionoflyophilisedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.ExpiryDate12monthsafterpurchaseGeneralReferences1.HatakenakaS,KuoCH,MikiN.Analysisofadistinctiveproteininchickretinaduringdevelopment.BrainRes.312:155-63(1983).2.KunoT,KajimotoY,HashimotoT,MukaiH,ShiraiY,SahekiS,TanakaC.CDNAcloningofaneuralvisinin-likeCa(2+)-bindingprotein.BiochemBiophysResCommun.184:1219-25(1992).3.PolymeropoulosMH,IdeS,SoaresMB,LennonGG.SequencecharacterizationandgeneticmappingofthehumanVSNL1gene,ahomologueoftheratvisinin-likepeptideRNVP1.Genomics.29:273-5(1995).4.BernsteinHG,BaumannB,DanosP,DiekmannS,BogertsB,GundelfingerED,BraunewellKH.Regionalandcellulardistributionofneuralvisinin-likeproteinimmunoreactivities(VILIP-1andVILIP-3)inhumanbrain.JNeurocytol.28:655-62(1999).5.PaterliniM,RevillaV,GrantAL,WisdenWExpressionoftheneuronalcalciumsensorproteinfamilyintheratbrain..Neuroscience.99:205-16(2000)6.LaterzaOF,ModurVR,CrimminsDL,OlanderJV,LandtY,LeeJM,LadensonJH.Identificationofnovelbrainbiomarkers.Clin.Chem.9:1713-21(2006)7.LeeJM,BlennowK,AndreasenN,LaterzaO,ModurV,OlanderJ,GaoF,OhlendorfM,LadensonJH.ThebraininjurybiomarkerVLP-1isincreasedinthecerebrospinalfluidofAlzheimerdiseasepatients.Clin.Chem.10:1617-23(2008).8.TarawnehR,D"AngeloG,MacyE,XiongC,CarterD,CairnsNJ,FaganAM,HeadD,MintunMA,LadensonJH,LeeJM,MorrisJC,HoltzmanDM.Visinin-likeprotein-1:diagnosticandprognosticbiomarkerinAlzheimerdisease.AnnNeurol.70:274-85(2011)doi:10.1002/ana.22448.

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。