首页 > Biosensis > Biosensis/Rabbit antibody to alpha synuclein (129-140): whole serum/R-075-100/100 µl

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Biosensis/Rabbit antibody to alpha synuclein (129-140): whole serum/R-075-100/100 µl

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R-075-100

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DescriptionAlphasynucleinisanabundant140aminoacidneuronalprotein,expressedprimarilyatpresynapticterminalsinthecentralnervoussystem.FUNCTION:Maybeinvolvedintheregulationofdopaminereleaseandtransport.Solubleprotein,normallylocalizedprimarilyatthepresynapticregionofaxons,whichcanformfilamentousaggregatesthatarethemajornonamyloidcomponentofintracellularinclusionsinseveralneurodegenerativediseases(synucleinopathies).Inducesfibrillizationofmicrotubule-associatedproteintau.Reducesneuronalresponsivenesstovariousapoptoticstimuli,leADIngtoadecreasedcaspase3activation.TISSUESPECIFICITY:Expressedprincipallyinbrainbutisalsoexpressedinlowconcentrationsinalltissuesexaminedexceptinliver.Concentratedinpresynapticnerveterminals.SUBUNIT:Solublemonomerwhichcanformfilamentousaggregates.InteractswithUCHL1.InteractswithphospholipaseDandhistones.SUBCELLULARLOCATION:Cytoplasm.Membrane.Nucleus.Note=Membrane-boundindopaminergicneurons.Alsofoundinthenucleus.ALTERNATIVEPRODUCTS:3namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.BatchNo.SeeproductlabelUnitsize100µlAntigenAsyntheticpeptide(SEEGYQDYEPEA)correspondingtotheC-terminalofhumanalphasynucleinprotein(aa129-140)conjugatedtoBlueCarrierProteinhasbeenusedastheimmunogen.Thepeptideishomologouswiththecorrespondingsequencederivedfromalphasynucleinproteininmonkeyandpig.OtherNamesNon-AbetacomponentofADamyloid;Non-A4componentofamyloidprecursor;NACP;SNCA;PARK1;AccessionP37840SYUA_HUMAN;ProducedinRabbitPurityWholeserumApplicationsIHC,WB.Adilutionof1:500to1:3000isrecommendedforbothapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityImmunohistochemicalandwesternblotanalysisofhumanbrainindicatesahighlevelofspecificityforthisantiserum.Cross-reactivityThisantibodyisknowntoreactwithhuman,mouseandratalphasynuclein.Otherspecieshavenotyetbeentested.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseSpecificReferences1.TinsleyR.B.etal(2010)Sensitiveandspecificdetectionofalpha-synucleininhumanplasmaJNeurosciRes.2010Sep;88(12):2693-700.References1.Lundvig,etalBrainResMolBrainRes134,3-17(Mar24,2005).2.Bennett,PharmacolTher105,311-31(Mar,2005).3.Vekrellis,etal.,MolNeurobiol30,1-21(Aug,2004).4.Martin,etal.,ProteinPeptLett11,229-37(Jun,2004).5.Doherty,etal.,ActaNeuropathol(Berl)107,169-75(Feb,2004).6.Goedert,CurrOpinGenetDev11,343-51(Jun,2001).7.Saito,etal.,JNeurolSci177,48-59(Aug1,2000).8.Luckingetal.CellMolLifeSci.2000Dec;57(13-14):1894-908.9.Kahle,etal.,AnnNYAcadSci920,33-41(2000).10.Clayton,etal.,TrendsNeurosci21,249-54(Jun,1998).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。