首页 > Biosensis > Biosensis/Rabbit antibody to beta synuclein (108-125): whole serum/R-056-100/100 µl

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Biosensis/Rabbit antibody to beta synuclein (108-125): whole serum/R-056-100/100 µl

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R-056-100

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DescriptionBeta-synucleinisanon-amyloidcomponentofsenileplaquesfoundinAlzheimerdisease.ItcouldactasaregulatorofSNCAaggregation.Itprotectsneruronsfromstaurosporineand6hydroxydopamine-stimulatedcapspaseactivationinap53-dependentmanner.Itlocalisestothecytoplasmanditispredominantlyexpressedinthebrainwhereitismostconcentratedinpresynapticnerveterminals.Thisproteinisphosphorylated.ThisproteinisalsoassociatedwiththediseaseBrainironaccumulationtype1(NBIA1).BatchNo.SeeproductlabelUnitsize100µlAntigenAsyntheticpeptide(IEPLMEPEGSYEDPPQE)ofhumanbetasynucleinprotein(aa:108-125)conjugatedtodiptheriatoxidhasbeenusedastheimmunogen.OtherNamesSNCBAccessionQ16143SYUB_HUMAN;ProducedinRabbitPurityWholeserumApplicationsIHC,WB,immunoblot.Adilutionof1:500to1:2000isrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityLessthan0.1%crossreactivitytohumanalphasynucleinCross-reactivityThisantiserumisknowntoreactwithhumanandratbetasynuclein.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseSpecificReferences1.IsraeliE.andSharonR.(2009)Beta-synucleinoccursinvivoinlipid-associatedoligomersandformshetero-oligomerswithalpha-synucleinJNeuRochem.2009Jan;108(2):465-74References1.Lundvig,etalBrainResMolBrainRes134,3-17(Mar24,2005).2.Bennett,PharmacolTher105,311-31(Mar,2005).3.Vekrellis,etal.,MolNeurobiol30,1-21(Aug,2004).4.Martin,etal.,ProteinPeptLett11,229-37(Jun,2004).5.Doherty,etal.,ActaNeuropathol(Berl)107,169-75(Feb,2004).6.Goedert,CurrOpinGenetDev11,343-51(Jun,2001).7.Saito,etal.,JNeurolSci177,48-59(Aug1,2000).8.Luckingetal.CellMolLifeSci.2000Dec;57(13-14):1894-908.9.Kahle,etal.,AnnNYAcadSci920,33-41(2000).10.Clayton,etal.,TrendsNeurosci21,249-54(Jun,1998).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。