首页 > Biosensis > Biosensis/Rabbit antibody to beta synuclein (C-terminal domain): IgG/R-1683-500/500 ug

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Biosensis/Rabbit antibody to beta synuclein (C-terminal domain): IgG/R-1683-500/500 ug

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R-1683-500

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Biosensis

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4000-520-616

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DescriptionBeta-synucleinisasolublecytoplasmicproteinassociatedwithsynapticvesiclesandamemberofthesynucleinfamily.Mutationsinalpha-synucleincauseearlyonsetParkinson"sdisease.Expressionofbetasynucleinmaymodulatealpha-synucleinaggregationfoundinParkinson"sdisease.BatchNo.SeeproductlabelUnitsize500ugAntigenAsyntheticpeptide(AQEAAEEPLIEPLME-C)correspondingtohumanβ-synuclein[99-113]intheC-terminaldomainconjugatedviaadditionalC-terminalCystoDiphtheriatoxoid.AntibodyTypePolyclonalApplicationsWBandIHC.Adilutionof1:500to1:1,000isrecommendedforWesternblot.β-synucleinisasolubleproteinof134aminoacidsanddetectedwith17kDamobilitybywesternblotting.ByIHCtheantibodydetectssynapticsitesinhumanbrainformaldehyde-treatedfrozentissue.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityConfirmedbyWBusingsolublemouseandhumanbrainextracts,reactivityformajorproductdiminishedbypeptideabsorption.Doesnotdetectalpha-synucleinastestedwithrecombinantproteinanddoesnotreactwithLewybodiesinhumanDementiawithLewyBodiesorParkinson"sdiseasebraintissuesections.SpeciesAgainstHumanandmouseβ-synucleinarehighlyconserved,socross-reactivitywithotherspeciesisexpected.FormLyophilizedfromPBS,pH7.4.Containsnopreservative.ReconstitutionReconstitutein500µLofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageLyophilizedat2-4°C.Afterreconstitution,storeat-20°Cinundilutedaliquotsforupto6months.Theantibodymaybestoredshorttermat2-4°Cwithanappropriateantibacterialagent.Avoidfreeze-thawcycles.ExpiryDate12monthsafterpurchaseReferencesCulvenor,J.G.,McLean,C.A.,Cutt,S.,Campbell,B.C.V.,Maher,F.,Jäkälä,P.,Hartmann,T.,Beyreuther,K.,Masters,C.M.,andLi,Q.-X.(1999)Non-AβcomponentofAlzheimersdiseaseamyloid(NAC)revisited:NACandα-synucleinarenotassociatedwithAβamyloid.Am.J.Path.155,1173-1181.Culvenor,J.G.,Rietze,R.L.,Bartlett,P.F.,Masters,C.L.,andLi,Q.-X.(2002)Oligodendrocytesfromneuralstemcellsexpressα-synuclein:IncreasednumbersfromPresenilin1deficientmice.NeuroReport13,1305-1308.Li,Q.X.,Campbell,B.C.V.,McLean,C.A.,Thyagarajan,D.,Gai,W.P.,Kapsa,R.M.,Beyreuther,K.,Masters,C.L.,andCulvenor,J.G.(2002)Plateletα-andγ-synucleinsinParkinson"sdiseaseandnormalcontrolsubjects.JournalofAlzheimersDisease4,309-315.Quilty,M.C.,Gai,W.-P.,Pountney,D.L.,West,A.K.,andVickers,J.C.(2003)Localizationofalpha,beta,andgammasynucleinduringneuronaldevelopmentandalterationsassociatedwiththeneuronalresponsetoaxonaltrauma.ExpNeurol182,195-207.George,S.Mok,S.S.,Nurjono,M.,Ayton,S.,Finkelstein,D.I.,Masters,C.L.,Li,Q.-X.andCulvenor,J.G.(2010)α-SynucleintransgenicmicerevealcompensatoryincreasesinParkinson"sDisease-associatedproteinsDJ-1andParkinandhaveenhancedα-synucleinandPINK1levelsafterrotenonetreatment.J.Mol.Neurosci.42,243-254.Ia,K.K.,Jeschke,G.R.,Deng,Y.,Kamaruddin,M.A.,Williamson,N.A.,Scanlon,D.B.,CULVENOR,J.G.,Hossain,M.I.,Purcell,A.W.,Liu,S.,Zhu,H.J.,Catimel,B.,Turk,B.E.andCheng,H.C.(2011)DefiningthesubstratespecificitydeterminantsrecognizedbytheactivesiteofC-TerminalSrcKinase-HomologousKinase(CHK)andidentificationofbetaSynucleinasapotentialCHKphysiologicalsubstrate.Biochemistry,50,6667-6677

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。