首页 > Biosensis > Biosensis/Rabbit antibody to gamma synuclein (114-127): whole serum/R-058-100/100 µl

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Biosensis/Rabbit antibody to gamma synuclein (114-127): whole serum/R-058-100/100 µl

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R-058-100

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DescriptionFUNCTION:Playsaroleinneurofilamentnetworkintegrity.Maybeinvolvedinmodulatingaxonalarchitectureduringdevelopmentandintheadult.Invitro,increasesthesusceptibilityofneurofilament-Htocalcium-dependentproteases.Mayalsofunctioninmodulatingthekeratinnetworkinskin.ActivatestheMAPKandElk-1signaltransductionpathway.SUBUNIT:Maybeacentrosome-associatedprotein.SUBCELLULARLOCATION:Cytoplasm;perinuclearregion.Centrosome.Spindle.Associatedwithcentrosomesinseveralinterphasecells.Inmitoticcells,localizedtothepolesofthespindle.TISSUESPECIFICITY:Highlyexpressedinbrain,particularlyinthesubstantianigra.Alsoexpressedinthecorpuscallosum,heart,skeletalmuscle,ovary,testis,colonandspleen.Weakexpressioninpancreas,kidneyandlung.PTM:Phosphorylated.PhosphorylationbyGRK5appearstooccuronresiduesdistinctfromtheresiduephosphorylatedbyotherkinases.DISEASE:Brainironaccumulationtype1(NBIA1,alsocalledHallervorden-Spatzsyndrome),arareneuroaxonaldystrophy,ishistologicallycharacterizedbyaxonalspheroids,irondeposition,Lewybody(LB)-likeintraneuronalinclusions,glialinclusionsandneurofibrillarytangles.SNCGisfoundinspheroidsbutnotininclusions.SIMILARITY:Belongstothesynucleinfamily.BatchNo.SeeproductlabelUnitsize100µlAntigenAsyntheticpeptide(EKEEVAEEAQSGGD)aspartofhumangammasynucleinprotein(aa:114-127)conjugatedtodiptheriatoxidhasbeenusedastheimmunogen.OtherNamesPersyn;Breastcancer-specificgene1protein;Synoretin;BCSG1;PERSYN;PRSN;SNCG;SR;AccessionO76070SYUG_HUMAN;ProducedinRabbitPurityWholeserumApplicationsIHC,WB.Adilutionof1:500to1:1000isrecommendedforbothapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityImmunohistochemical/westernblotanalysisindicateahighlevelofspecificityforthisantiserumforgammasynuclein.Cross-reactivityThisantiserumisknowntoreactwithhumanandratgammasynuclein.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseReferences1.Lundvig,etalBrainResMolBrainRes134,3-17(Mar24,2005).2.Bennett,PharmacolTher105,311-31(Mar,2005).3.Vekrellis,etal.,MolNeurobiol30,1-21(Aug,2004).4.Martin,etal.,ProteinPeptLett11,229-37(Jun,2004).5.Doherty,etal.,ActaNeuropathol(Berl)107,169-75(Feb,2004).6.Goedert,CurrOpinGenetDev11,343-51(Jun,2001).7.Saito,etal.,JNeurolSci177,48-59(Aug1,2000).8.Luckingetal.CellMolLifeSci.2000Dec;57(13-14):1894-908.9.Kahle,etal.,AnnNYAcadSci920,33-41(2000).10.Clayton,etal.,TrendsNeurosci21,249-54(Jun,1998).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。