首页 > Biosensis > Biosensis/Rabbit antibody to human APP: whole serum/R-070-100/100 µl

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Biosensis/Rabbit antibody to human APP: whole serum/R-070-100/100 µl

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R-070-100

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Biosensis

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DescriptionFUNCTION:Functionsasacellsurfacereceptorandperformsphysiologicalfunctionsonthesurfaceofneuronsrelevanttoneuritegrowth,neuronaladhesionandaxonogenesis.Involvedincellmobilityandtranscriptionregulationthroughprotein-proteininteractions.CanpromotetranscriptionactivationthroughbindingtoAPBB1/Tip60andinhibitNotchsignalingthroughinteractionwithNumb.Couplestoapoptosis-inducingpathwayssuchasthosemediatedbyG(O)andJIP.InhibitsG(o)alphaATPaseactivity.ActsasakinesinImembranereceptor,mediatingtheaxonaltransportofbeta-secretaseandpresenilin1.Maybeinvolvedincopperhomeostasis/oxidativestressthroughcopperionreduction.CanregulateneuriteoutgrowththroughbindingtocomponentsoftheextracellularmatrixsuchasheparinandcollagenIandIV.FUNCTION:Beta-amyloidpeptidesarelipophilicmetalchelatorswithmetal-reducingactivity.Bindtransientmetalssuchascopper,zincandiron.Ratandmousebeta-amyloidpeptidesbindonlyweaklytransientmetalsandhavelittlereducingactivityduetosubstitutionsoftransientmetalchelatingresidues.Beta-APP42mayactivatemononuclearphagocytesinthebrainandelicitinflammatoryresponses.PromotesbothtauaggregationandTPKII-mediatedphosphorylation(Bysimilarity).FUNCTION:Thegamma-CTFpeptidesaswellasthecaspase-cleavedpeptides,includingC31,arepotentenhancersofneuronalapoptosis.SUBUNIT:Binds,viaitsC-terminus,tothePIDdomainofseveralcytoplasmicproteins,includingAPBBfamilymembers,theAPBAfamily,MAPK8IP1,SHC1,NumbandDab1.BindingtoDab1inhibitsitsserinephosphorylation.AlsointeractswithGPCR-likeproteinBPP,FPRL1,APPBP1,IB1,KNS2(viaitsTPRdomains),APPBP2(viaBaSS)andDDB1.Invitro,itbindsMAPTviatheMT-bindingdomains.AssociateswithmicrotubulesinthepresenceofATPandinakinesin-dependentmanner.Interacts,throughaC-terminaldomain,withGNAO1.Amyloidbeta-42bindsCHRNA7inhippocampalneurons.Beta-amyloidassociateswithHADH2.TISSUESPECIFICITY:differentisoformsindifferenttissues:kidney.brain.liver.hippocampus,substanianigraparscompactaandcerebellum.Inthecerebellum,alltheisoformsareabundantlyexpressedinPurkinjecells.BatchNo.SeeproductlabelUnitsize100µlAntigenSyntheticpeptides(C-ETHLHWHTVAKET,aa:145-157;C-HAHFQKAKERLEAKHRER,aa:388-405;C-KKKQYTSIHHGVVE,aa:724-737)aspartsofhumanAPPisoformAconjugatedtoKLHOtherNamesAmyloidbetaA4protein;ABPP;Alzheimerdiseaseamyloidprotein;Cerebralvascularamyloidpeptide;CVAP;Proteasenexin-II;PN-II;APPI;PreA4;A4;AD1AccessionAPP_HUMANProducedinRabbitPurityWholeserumApplicationsIHC.Recommendedtobeusedatadilutionof1:500to1:3000forimmunohistochemistry.Thisantiserumhasnotyetbeentestedforwesternblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificitySpecificityforAPPwasconfirmedbyIHC.Cross-reactivityThisantiserumisknowntoreactwithratAPP.Reactivitywithotherspecieshavenotyetbeentested.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedIDbetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.References1.Wilson,C.A.,etal.,J.Neurosci.Res.74:361-369(2003).2.Andreasen,N.,etal.,WorldJ.Biol.Psychiatry4:147-155(2003).3.Guenette,S.Y.NeuromolecularMed.4:147-160(2003).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。