首页 > Biosensis > Biosensis/Rabbit antibody to human Microtubule-associated protein Tau: whole serum/R-184-100/100 µl

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Biosensis/Rabbit antibody to human Microtubule-associated protein Tau: whole serum/R-184-100/100 µl

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R-184-100

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DescriptionFUNCTION:PromotesmicrotubuleassemblyandstABIlity,andmightbeinvolvedintheestablishmentandmaintenanceofneuronalpolarity.TheC-terminusbindsaxonalmicrotubuleswhiletheN-terminusbindsneuralplasmamembranecomponents,suggestingthattaufunctionsasalinkerproteinbetweenboth.Axonalpolarityispredeterminedbytaulocalization(intheneuronalcell)inthedomainofthecellbodydefinedbythecentrosome.TheshortisoformsallowplasticityoftheCytoskeletonwhereasthelongerisoformsmaypreferentiallyplayaroleinitsstabilization.SUBCELLULARLOCATION:Cytoplasm;cytosol.Cellmembrane.Mostlyfoundintheaxonsofneurons,inthecytosolandinassociationwithplasmamembranecomponents.ALTERNATIVEPRODUCTS:8namedisoformsproducedbyalternativesplicing.Additionalisoformsseemtoexist.Isoformsdifferfromeachotherbythepresenceorabsenceofupto5ofthe15exons.Oneoftheseoptionalexonscontainstheadditionaltau/MAPrepeat.TISSUESPECIFICITY:Expressedinneurons.IsoformPNS-tauisexpressedintheperipheralnervoussystemwhiletheothersareexpressedinthecentralnervoussystem.DEVELOPMENTALSTAGE:Four-repeat(typeII)tauisexpressedinanadult-specificmannerandisnotfoundinfetalbrain,whereasthree-repeat(typeI)tauisfoundinbothadultandfetalbrain.DOMAIN:Thetau/MAPrepeatbindstotubulin.InAlzheimerdisease,theneuronalcytoskeletoninthebrainisprogressivelydisruptedandreplacedbytanglesofpairedhelicalfilamentsandstraightfilaments,mainlycomposedofhyperphosphorylatedformsofMicrotubule-associatedproteinTau.DefectsinMicrotubule-associatedproteinTauareacauseoffrontotemporaldementiaandparkinsonismlinkedtochromosome17,aswellasanumberofotherneurodegenerativediseases.BatchNo.SeeproductlabelUnitsize100µlAntigenRecombinanthumanMicrotubule-associatedproteinTau,purifiedfromE.coli.OtherNamesNeurofibrillarytangleprotein;Pairedhelicalfilament-tau;PHF-tau;MAPT;MTBT1;TAUAccessionTAU_HUMANProducedinRabbitPurityWholeserumApplicationsWBanddirectELISA(Human).ForWBadilutionof1:500isrecommended.ThisantibodyhasbeenshowntodetectthepurifiedrecombinantTauexpressedinE.ColiaswellasanumberofTauisoformsinporcinecytosol.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificitySpecificitywasdemonstratedbywesternblot.20ngrecombinantTauiseasilydetectedwithsmallerfragmentslikelyrepresentingdegradationproductsfromthepurifiedprotein,whichhasbeenexpressedinE.Coli.Cross-reactivityThisantiserumisknowntoreactwithhumanandpigMicrotubule-associatedTauproteins.Otherspecieshavenotyetbeentested.BlastitIfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforhigherstability,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseSpecificReferencesBallazS,MoralesI,RodríguezM,ObesoJA.(2013)Ascorbatepreventscelldeathfromprolongedexposuretoglutamateinaninvitromodelofhumandopaminergicneurons.J.NeurosciRes.Aug302013[Eprint]References1.GoedertM,etal.(1988)Proc.Natl.Acad.Sci.U.S.A.85:4051-4055.2.GoedertM,etal.(1989)Neuron3:519-526.3.LeeG,etal.(1989)Neuron2:1615-1624.4.AndreADIsA,etal.(1992)Biochemistry31:10626-10633.5.JakesR,etal.(1991)EMBOJ.10:2725-2729.6.CrippsD,etal.(2006)J.Biol.Chem.281:10825-10838.7.MaasT,etal.(2000)J.Biol.Chem.275:15733-15740.8.NacharajuP,etal.(1997)J.NeuRochem.69:1709-1719.9.WintjensR,etal.(2001)J.Biol.Chem.276:25150-25156.10.OlivaR,etal.(2004)Ann.Neurol.55:448-449.

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。