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Biosensis/Rabbit antibody to pan synuclein: whole serum/R-060-100/100 µl
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BatchNo.SeeproductlabelUnitsize100µlAntigenAsyntheticpeptide(AKEGVVAAAEKTKQGV)asaconsensuspartofhumanalpha-,beta-,andgammasynucleinproteinsconjugatedtodiphteriatoxoidhasbeenusedastheimmunogen.AccessionSYUA_HUMANSYUB_HUMANSYUG_HUMANProducedinRabbitPurityWholeserumApplicationsIHC,WBandimmunoblot.Adilutionof1:1000isrecommendedfortheseapplications.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityOverlapspecificimmunohistochemicalstainingofalpha-,beta-andgammasynucleinsCross-reactivityThisantiserumrecogniseshumanandratalpha-,beta-andgammasynucleins.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseSpecificReferences1.UlusoyA.etal(2010)EurJNeurosci.2010Aug;32(3):409-222.NäsströmT.etal(2010)Thelipidperoxidationproducts4-oxo-2-nonenaland4-hydroxy-2-nonenalpromotetheformationofα-synucleinoligomerswithdistinctbiochemical,morphological,andfunctionalproperties.FreeRADIcBiolMed.2010Dec1.3.EslamboliA.etal(2007)Long-termconsequencesofhumanalpha-synucleinoverexpressionintheprimateventralmidbrain.Brain.2007Mar;130(Pt3):799-815.4.Mukaetova-LadinskaE.B.etal(2008)Alpha-andgamma-synucleinproteinsarepresentincerebrospinalfluidandareincreasedinagedsubjectswithneurodegenerativeandvascularchanges.DementGeriatrCognDisord.2008;26(1):32-42.References1.OpazoF.etalJNeuRochem.2008Jul;106(2):529-402.Lundvig,etalBrainResMolBrainRes134,3-17(Mar24,2005).3.Bennett,PharmacolTher105,311-31(Mar,2005).4.Vekrellis,etal.,MolNeurobiol30,1-21(Aug,2004).5.Martin,etal.,ProteinPeptLett11,229-37(Jun,2004).6.Doherty,etal.,ActaNeuropathol(Berl)107,169-75(Feb,2004).7.Goedert,CurrOpinGenetDev11,343-51(Jun,2001).8.Saito,etal.,JNeurolSci177,48-59(Aug1,2000).9.Luckingetal.CellMolLifeSci.2000Dec;57(13-14):1894-908.10.Kahle,etal.,AnnNYAcadSci920,33-41(2000).11.Clayton,etal.,TrendsNeurosci21,249-54(Jun,1998).

Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。

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