首页 > Biosensis > Biosensis/Rabbit antibody to Parkin (295-311): whole serum/R-114-100/100 µl

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Biosensis/Rabbit antibody to Parkin (295-311): whole serum/R-114-100/100 µl

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R-114-100

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4000-520-616

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DescriptionFUNCTION:FunctionswithinamultiproteinE3ubiquitinligasecomplex,catalyzingthecovalentattachmentofubiquitinmoietiesontosubstrateproteins.ThesesubstratesincludeSYT11,CCNE1,GPR37,STUB1,a22kDaO-linkedglycosylatedisoformofSNCAIPandSEPT5.Mayplayamoregeneralroleintheubiquitinproteasomalpathwaybyparticipatingintheremovaland/ordetoxificationofabnormallyfoldedordamagedprotein.LossofthisubiquitinligaseactivityappearstobethemechanismunderlyingpathogenesisofPARK2.Mayprotectneuronsagainstalphasynucleintoxicity,proteasomaldysfunction,GPR37accumulation,andkainate-inducedexcitotoxicity.Mayplayaroleincontrollingneurotransmittertraffickingatthepresynapticterminalandincalcium-dependentexocytosis.RegulatescyclinEduringneuronalapoptosis.Mayrepresentatumorsuppressorgene.SUBCELLULARLOCATION:Cytoplasm.Co-localizeswithSTY11inneutrites.Co-localizeswithSNCAIPinbrainstemLewybodies.TISSUESPECIFICITY:Highlyexpressedinthebrainincludingthesubstantianigra.Expressedinheart,testisandskeletalmuscle.Expressionisdown-regulatedorabsentintumorbiopsies,andabsentinthebrainofPARK2patients.Overexpressionprotectsdopamineneuronsfromkainate-mediatedapoptosis.BatchNo.SeeproductlabelUnitsize100µlAntigenAsyntheticpeptide(NSLIKELHHFRILGEEQ)aspartofhumanParkinconjugatedtoKLHhasbeenusedastheimmunogen.OtherNamesUbiquitinE3ligasePRKN;Parkinsonjuvenilediseaseprotein2;Parkinsondiseaseprotein2;PARK2;PRKNAccessionPRKN2_HUMANProducedinRabbitPurityWholeserumApplicationsIHC,WB.Adilutionof1:1000isrecommendedforimmunohistochemistryand1:2000forwesternblot.Nicestainingisachievedinneuronalandcytoplasmicgranulessectionstreatedwithcitratebufferforantigenretrieval.FewinclusionsarestainedbutthesewerenotpositivelyidentifiedasLewybodies.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThisantiserumisknowntobehighlyspecificforParkinshownbyIHCandWB.Cross-reactivityThisantibodyisknowntoreactwithratandhumanParkin.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseSpecificReferences1.SongY.J.C.etal(2009).Degenerationindifferentparkinsoniansyndromesrelatestoastrocytetypeandastrocyteproteinexpression.J.Neuropathol.Exp.Neurol.Oct2009;68(10):1073-10832.HuangY.etal(2008).LRRK2andparkinimmunoreactivityinmultiplesystematrophyinclusions.ActaNeuropathol.2008Dec;116(6):639-46.References1.Hottorietal.(1998)BiochemBiophysResCommun.249(3):754-7582.Kitadaetal.(1998).Nature.392:605-6083.Kumru,H.,etal.,Ann.Neurol.56(4):599-603(2004).4.Pigullo,S.,etal.,ParkinsonismRelat.Disord.10(6):357-362(2004).5.Yao,D.,etal.,Proc.Natl.Acad.Sci.U.S.A.101(29):10810-10814(2004).6.West,A.B.,etal.,J.Biol.Chem.279(28):28896-28902(2004).7.Wang,F.,etal.,GenesChromosomesCancer40(2):85-96(2004).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。