首页 > Biosensis > Biosensis/Rabbit antibody to Parkin (305-323): whole serum/R-113-100/100 µl

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Biosensis/Rabbit antibody to Parkin (305-323): whole serum/R-113-100/100 µl

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R-113-100

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Biosensis

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DescriptionFUNCTION:FunctionswithinamultiproteinE3ubiquitinligasecomplex,catalyzingthecovalentattachmentofubiquitinmoietiesontosubstrateproteins.ThesesubstratesincludeSYT11,CCNE1,GPR37,STUB1,a22kDaO-linkedglycosylatedisoformofSNCAIPandSEPT5.Mayplayamoregeneralroleintheubiquitinproteasomalpathwaybyparticipatingintheremovaland/ordetoxificationofabnormallyfoldedordamagedprotein.LossofthisubiquitinligaseactivityappearstobethemechanismunderlyingpathogenesisofPARK2.Mayprotectneuronsagainstalphasynucleintoxicity,proteasomaldysfunction,GPR37accumulation,andkainate-inducedexcitotoxicity.Mayplayaroleincontrollingneurotransmittertraffickingatthepresynapticterminalandincalcium-dependentexocytosis.RegulatescyclinEduringneuronalapoptosis.Mayrepresentatumorsuppressorgene.SUBCELLULARLOCATION:Cytoplasm.Co-localizeswithSTY11inneutrites.Co-localizeswithSNCAIPinbrainstemLewybodies.TISSUESPECIFICITY:Highlyexpressedinthebrainincludingthesubstantianigra.Expressedinheart,testisandskeletalmuscle.Expressionisdown-regulatedorabsentintumorbiopsies,andabsentinthebrainofPARK2patients.Overexpressionprotectsdopamineneuronsfromkainate-mediatedapoptosis.BatchNo.SeeproductlabelUnitsize100µlAntigenAsyntheticpeptide(RILGEEQYNRYQQYGAEEC)aspartofhumanParkinconjugatedtodiphtheriatoxoidhasbeenusedastheimmunogen.OtherNamesUbiquitinE3ligasePRKN;Parkinsonjuvenilediseaseprotein2;Parkinsondiseaseprotein2;PARK2;PRKNAccessionPRKN2_HUMANProducedinRabbitPurityWholeserumApplicationsIHC,WB,immunoblot,1-siteELISA.Adilutionof1:500to1:2000isrecommendedfortheseapplications.Thisantiserumstainstrigeminalmotorneuronsinratbrainstem.A50kDabandwasidentifiedinratbrainextractusingwesternblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThisantiserumiisknowntospecificallyrecogniseParkinshownbyIHCandWB.Cross-reactivityThisantibodyisknowntoreactwithParkinofguineapigandrat.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseSpecificReferences1.E.RubiodelaTorreetal(2009)Combinedkinaseinhibitionmodulatesparkininactivation.HumMolGenet.2009Mar1;18(5):809-23.2.D"AgataV.etal(2009)Parkinexpressionprofileindopamined3receptorknock-outmicebrains.NeuRochemRes.2009Feb;34(2):327-32.3.TamoW.etal(2007)Parkinisexpressedinvascularendothelialcells.NeurosciLett.2007Jun4;419(3):199-201.4.TrimmerP.A.etal(2004)Parkinson"sdiseasetransgenicmitochondrialcybridsgenerateLewyinclusionbodies.JNeurochem.2004Feb;88(4):800-12.5.DenisonS.R.etal(2004)AlterationsinthecommonfragilesitegeneParkininovarianandothercancers.Oncogene.2003Nov13;22(51):8370-8.6.PawlykA.C.etal(2003)Novelmonoclonalantibodiesdemonstratebiochemicalvariationofbrainparkinwithage.JBiolChem.2003Nov28;278(48):48120-8.7.HorowitzJ.M.etal(2001)Spatialdistribution,cellularintegrationandstagedevelopmentofParkinproteininXenopusbrainBrainResDevBrainRes.2001Jan31;126(1):31-41.References1.Hottorietal.(1998)BiochemBiophysResCommun.249(3):754-7582.Kitadaetal.(1998).Nature.392:605-608

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。