首页 > Biosensis > Biosensis/Rabbit antibody to Sequestosome 1: whole serum/R-162-100/100 µl

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Biosensis/Rabbit antibody to Sequestosome 1: whole serum/R-162-100/100 µl

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R-162-100

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Biosensis

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4000-520-616

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DescriptionSequestosome1isanadapterproteinwhichbindsubiquitinandmayregulatetheactivationofNFKB1byTNF-alpha,nervegrowthfactorandinterleukin-1.Itmayregulatesignalingcascadesthroughubiquitinationandmayalsobeinvolvedincelldifferentiation,apoptosis,immuneresponseandregulationofK(+)channels.Itispresentasahomooligomerorheterooligomerandlocalisestothecytoplasm,lateendosomeandnucleus.Incardiacmusclesitlocalisestothesarcomericband.ItaccumulatesinneurofibrillarytanglesandinLewybodiesofneuronsfromindividualswithAlzheimerandParkinsondiseaserespectively.ItisalsoenrichedinRosenthalfibersofpilocyticastrocytomaandinlivercellsitaccumulatesinMallorybodiesassociatedwithalcoholichepatitis,Wilsondisease,indianchildhoodcirrhosisandinhyalinebodiesassociatedwithhepatocellularcarcinoma.Sequestosome1isubiquitouslyexpressedandtodate,thereare2namedisoformsproducedbyalternativesplicing.Defectsinsequestosome1causesporADIcandfamilialPagediseaseofbone(PDB).Thisisametabolicbonediseasecharacterisedbyfocalareasofincreasedanddisorganisedboneturn-overduetoactivatedosteoclasts.BatchNo.SeeproductlabelUnitsize100µlAntigenPeptideIGAALDTIQYSKHcorrespondingtotheC-terminalpartofhumanSequestosome1(aa:424-436)conjugatedtotheBlueCarrierProteinhasbeenusedastheimmunogen.OtherNamesPhosphotyrosine-independentligandfortheLckSH2domainof62kDa;ubiquitin-bindingproteinp62;EBI3-associatedproteinof60kDa;p60;EBIAP;SQSTM1;ORCA;OSILAccessionSQSTM_HUMANProducedinRabbitPurityWholeserumApplicationsIHC.Adilutionof1:500to1:5000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThespecificitywasconfirmedbyimmunohistochemicalanalysisonparaffinembeddedhumanbrain.Cross-reactivityThisantibodyisexpectedtorecognisep60inmouse,ratandbovine.Seetheimmunogenfieldalso.BlastitIfyouwouldliketousethisproductinanotherspeicesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability.ExpiryDate12monthsafterpurchase

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。