首页 > Biosensis > Biosensis/Rabbit antibody to SUMO-1 (6-21): whole serum/R-115-100/100 µl

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Biosensis/Rabbit antibody to SUMO-1 (6-21): whole serum/R-115-100/100 µl

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R-115-100

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4000-520-616

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DescriptionFUNCTION:Ubiquitin-likeproteinwhichbindstoawiderangeoftargetproteins.DoesnotseemtobeinvolvedinproteindegradationandmayfunctionasanantagoNISTofubiquitininthedegradationprocess.Playsaroleinanumberofcellularprocessessuchasnucleartransport,DNAreplicationandrepair,mitosisandsignaltransduction.InvolvedintargetingRANGAP1tothenuclearporecomplexproteinRANBP2.SUBUNIT:CovalentlyattachedtoanumberofproteinssuchasPML,RANGAP1,HIPK2,SP100,p53,p73alpha,MDM2,JUNandDNMT3B.AlsointeractswithHIF1A,HIPK2,HIPK3,CHD3,PIAS1,EXOSC9,TDG,RAD51andRAD52.SUBCELLULARLOCATION:Nucleus;nuclearmembrane.Nucleus;nucleoplasm;nuclearspeckle.Cytoplasm.SIMILARITY:Belongstotheubiquitinfamily.SMT3subfamily.SIMILARITY:Contains1ubiquitin-likedomain.BatchNo.SeeproductlabelUnitsize100µlAntigenAsyntheticpeptide(AKPSTEDLGDKKEGEY)aspartofhumanSUMO-1peptide(aa:6-21)conjugatedtodiphtheriatoxoidhasbeenusedastheimmunogen.ThisantigenishomologouswithSUMO-1ofrat.OtherNamesSmallubiquitin-relatedmodifier1;Ubiquitin-likeproteinSMT3C;SMT3homolog3;Ubiquitin-homologydomainproteinPIC1;Ubiquitin-likeproteinUBL1;GAP-modifyingprotein1;GMP1;Sentrin;SUMO1;SMT3C;SMT3H3;UBL1AccessionSUMO1_HUMANProducedinRabbitPurityWholeserumApplicationsIHC,WB.Adilutionof1:1000to1:2000isrecommendedforimmunohistochemistryand1:2000to1:4000forwesternblot.CelllysatefromHelaandNIH-3T3celllysatesmaybeusedasapositivecontrol,andforIHC,lungcarcinomamaybeused.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThisantiserumrecogniseshumanSUMO-1andnotubiquitin.Cross-reactivityThisantiserumisknowntocrossreactwithratandhumanSUMO-1.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeciesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseReferences1.Yang,S.H.etal.Mol.Cell13(4):611-617(2004).2.Ohshima,T.etal.J.Biol.Chem.278(51):50833-50842(2003).3.Bailey,D.etal.J.Biol.Chem.279(1):692-703(2004).4.Ling,Y.etal.NucleicAcidsRes.32(2):598-610(2004).5.Pountney,D.L.etal.Exp.Neurol.184(1):436-446(2003).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。