首页 > Biosensis > Biosensis/Rabbit antibody to Synphilin-1 (911-919): whole serum/R-117-100/100 µl

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Biosensis/Rabbit antibody to Synphilin-1 (911-919): whole serum/R-117-100/100 µl

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R-117-100

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Biosensis

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4000-520-616

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DescriptionSynucleinalphainteractingprotein(Synphilin-1)containsseveralprotein-proteininteractiondomainsandinteractswithalphasynucleininneurons.MutationsofSNCAIPhavebeenlinkedtoParkinsondisease.Theaminoacidsequenceofsynphilin-1sharesahighlevelofidentitywithitshumancounterpart,particularlyinregionscontainingankyrin-likemotifsandthecoiled-coildomain.Expressionpatternofsynphilin-1intissuesissimilarinbothmouseandhuman.Synphilin-1hasanimportantroleintheformationofaggregatesandcytotoxicityinParkinsondiseaseandalsoDorfinmaybeinvolvedinthepathogenicprocessbyubiquitylationofsynphilin-1.BatchNo.SeeproductlabelUnitsize100µlAntigenAsyntheticpeptide(CASKGKNKAA)aspartofhumansynphilin-1aconjugatedtoKLHhasbeenusedastheimmunogen.OtherNamesSynphilin-1aprotein;synucleinalphainteractingprotein;Synphilin-1;Synphilin1;SNCAIPAccessionSynphilin-1aprotein_HUMANProducedinRabbitPurityWholeserumApplicationsIHC,WB.Adilutionof1:1000to1:2000isrecommendedforimmunohistochemistryand1:500-1:1000forwesternblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityAhighlevelofspecificityhasbeenshownforthisantiserumbyIHConhumanbrain.Cross-reactivityThisantiserumisknowntoreactwithratandhumansynphilin-1a.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseReferences1.Kruger,R.CellTissueRes.318(1),195-199(2004)2.Lee,G.,etal.J.Biol.Chem.279(8),6834-6839(2004)3.Tanaka,M.,etal.J.Biol.Chem.279(6),4625-4631(2004)4.Nagano,Y.,etal.J.Biol.Chem.278(51),51504-51514(2003)5.Marx,F.P.,etal.Hum.Mol.Genet.12(11),1223-1231(2003)6.Junn,E.,etal.J.Biol.Chem.277(49),47870-47877(2002)7.Chung,K.K.,etal.Nat.Med.7(10),1144-1150(2001)8.Kawamata,H.,etal.J.NeuRochem.77(3),929-934(2001)9.Engelender,S.,etal.Nat.Genet.22(1),110-114(1999)

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。