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Biosensis/Rabbit polyclonal antibody to Human Caspase 6 (CASP-6;Mch-2), Affinity Purified/R-1705-100/100 ug
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DescriptionCaspasesplayseveralkeyrolesincellulargrowthanddevelopment,extracellularmatrixremodeling,woundhealing,homeostasis,andareimplicatedinawiderangeofdiseasesfromautoimmunedysfunctiontocancermetastasesaswell. CaspasesareCysteineASpartateProteaseswhichformafamilyofmetalloproteinasesofwhichtherearemorethanadozenmembers.Caspasesareallnormallyexpressedincellsasinactiveprecursorzymogensthatthengetactivatedviaproteolyticcleavagetoformactiveenzymecomplexes. Activationcanoccurbyseveralmeansandprogrammedcelldeath,orapoptosis,isamongthemoststudied,butthereareseveralotherssincecaspasesareinvolvedinsomanycriticalanddiseasestates. Amongthe14orsomembers,Caspase-6isparticularlyinterestingbecauseithasbeenimplicatedinplayingaroleinsomeneurodegenerativediseasesincludingAlzheimersandHuntingtonsdisease. Caspase-6hasbeenshowntocutamyloidprecursorprotein(APP),atposition720leADIngtothetoxicfragmentJcasp,whichisoneofthefragmentsfoundinamyloidplaqueswhicharebelievedtobeanindicatorofthedisease,andinHuntingtonsdisease,thespecificaminoacidsequence(IVLD586G)isrecognizedbyCaspase-6 ontheHuntingtonprotein(htt)inmicewithHuntingtonsdisease.Theproteolyticcleavageofhttliberatestoxicfragmentscontainingtheexpandedpolyglutaminetractthatareneurotoxicandthatstimulatesadditionalproteolyticactivityleadingtoapoptosisandneurodegeneration.MutationoftheCaspase-6siteinmicemodelwithAlzheimersandHuntingtonsdiseaseprovidesprotectionfromtheneuraldysfunction,suggestingacausalrelationshipbetweenCaspase-6cleavageandneurodegeneration.BiosensisispleasedtoofferarabbitpolyclonalantibodytohumanCaspase6thatreactsinparaffinembeddedimmunohistochemistryandwesternblottingforyourcontinuedresearchintoCaspase6anditspotentialrolesinbothnormalandpathologicalconditions.Unitsize100ugAntigenAsyntheticpeptidecorrespondingtoanaminoacidsequenceattheN-terminalofhumanCaspase6comprisingaminoacids24-44ofhumanCaspase6SequenceAFYKREMFDPAEKYKMDHRRRAntigenLocationN-terminalp18largesubunitAntigenLength21aminoacidsAntibodyTyperabbitpolyclonalIsotypeIgGOtherNamescaspase6;CASP6;CASP-6;Mch2;ApoptoticproteaseMch-2AccessionP55212(CASP6_HUMAN)ProducedinRabbitMolecularWeightMultiplelargesubunitfragmentsrecognizeddependingupondegreeofactivation.Fullycleavedlargesubunitis~18-20kDareduced,pre-cleavedproproteinis~29kDa,fulllengthuncleavedparentis~35kDaCompoundNameCaspase6PurityAffinitypurifiedpolyclonalIgGApplicationsWesternBlot:0.1ug-0.5ug/mLcelllysates,ECLdetectionImmunohistochemistry,paraffinembedded:0.8-2.0ug/mLwithHEIRantigenrecoveryImmunohistochemistry,frozensections:0.5-1.0ug/mLPLPfixationrecommended.SpecificityHumanCaspase6protein,noreactivitytootherhumancaspasesSpeciesAgainstHuman,otherspeciesnotyettestedCross-reactivityPotentialreactivitytomouseCaspase6baseduponsequencehomologybutasyetuntested.FormFreeze-driedpowderfromliquidcontainingPBS,5mgBSA,0.05mgThimerosaland0.05mgsodiumazide.AppearancedrypowderReconstitutionReconstitutevialin0.2mLofsteriledistilledwater.Thiswillproduceafinalconcentrationof500ug/mLofantibody.StorageStoredry,unopenedvialat-20Cforoneyear;afterreconstitutionaliquotintosingleusesizesandstoreat4Cforuptoonemonth;storealiquotsfrozenat-70Cforuptosixmonths,protectedfromlightandpreventmultiplefreezethawcycles.ExpiryDate1yearfromdateofpurchaseforunopenedvialonly.
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
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