首页 > Biosensis > Biosensis/Rabbit polyclonal antibody to Nicastrin, N-terminal domain: IgG/R-1686-500/500 ug

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Biosensis/Rabbit polyclonal antibody to Nicastrin, N-terminal domain: IgG/R-1686-500/500 ug

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R-1686-500

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DescriptionNicastrin,atype1membraneglycoprotein,isanessentialcomponentofthegammasecretasecomplexwhichiscriticalforthecleavageoftheamyloidprecursorproteinandothermembraneproteins.Nicastriniswidelyexpressedindifferenttissuetypes.ThisantibodydetectsallprocessedformsofNicastrin.BatchNo.SeeviallabelUnitsize500ugAntigenAsyntheticpeptide(RGNSVERKIYIPL-C)correspondingtohumanNicastrin[32-44]intheN-terminalregionconjugatedviaadditionalC-terminalCystoDiphtheriatoxoid.AntibodyTypePolyclonalProducedinRabbitApplicationsWBandIP.Suggestedconcentrationof3-10ug/mLisrecommendedforWB.Humanormousebrainsamplescommonlypreparedwithreducing(50mMDTT),urea(2.3M),SDS(1.5%)in62.5mMTris-HCLpH6.8samplebuffer(withoutboiling)heatingto50Cfor15min.UnprocessedfulllengthhumanNicastrinis709aminoacids,howeverthisproteincontainsanN-terminalsignalpeptidewhichisconsideredtoundergocleavageduringprocessingandtransittothecellplasmamembrane,inadditiontheproteinundergoesglycosylationtoproduceaglycoproteinofabout145kDaapparentMWbySDSPAGE.Biosensisrecommendsthattheoptimalworkingdilutionshouldbedeterminedbytheenduser.SpecificityConfirmedbyWBusingpeptideabsorption.SpeciesAgainstConfirmedbyWBusingpeptideabsorption.FormLyophilizedfromPBS,pH7.4.Containsnopreservative.ReconstitutionReconstitutein500µLofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageShorttermstorageat2-8°Cforoneweek.At-20°Casanundilutedliquidforupto12months.ExpiryDate12monthsafterpurchaseReferences1.Ilaya,N.T.,Evin,G.,Masters,C.L.,andCulvenor,J.G.(2004)Nicastrinexpressioninmouseperipheraltissuesisnotco-ordinatedwithPresenilinandishighinmuscle.J.NeuRochem.91,230-237.

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。