首页 > Biosensis > Biosensis/Rabbit polyclonal antibody to Presenilin 1 (1-20): IgG/R-1605-500/500 µg

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Biosensis/Rabbit polyclonal antibody to Presenilin 1 (1-20): IgG/R-1605-500/500 µg

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R-1605-500

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DescriptionPresenilin-1(PSEN1)isamulti-passmembraneproteinandcomponentofthegamma-secretasecomplex.PSEN1isthoughttoplayaroleinintracellularsignalingandgeneexpressionorinlinkingchromatintothenuclearmembrane.Itmayalsoplayaroleinhematopoiesis.DefectsinPSEN1areacauseofAlzheimerdiseasetype3(AD3),afamilialearly-onsetformofAlzheimerdisease(Ref:SWISS-Prot).BatchNo.SeeproductlabelUnitsize500µgAntigenAsyntheticpeptidecorrespondingtoaregion(1-20aa)fromtheN-terminusofhumanPresenilin1conjugatedtoDiptheriatoxoid.SequenceMTELPAPLSYFQNAQMSEDN-CAntibodyTypePolyclonalOtherNamesPresenilin1;PS-1;ProteinS182;PS1-CTF12;PSEN1;AD3;PS1;PSNL1;AccessionP49768PSN1_HUMAN;ProducedinRabbitApplicationsIFandWB.Suggesteddilutionof1:2,000isrecommendedforWB.OnSDS-PAGE,thepredominantformdetectedbythisantibodyistheN-terminalPresenilin1fragmentofapprox29kDa.TheuncleavedformofPresenilin1migratestoapprox45kDa.Humanandmousebrainsamplescommonlypreparedwithreducingagent(50mMDTT),urea(2.3M),SDS(1%)in62.5mMTris-HClpH6.8samplebufferheatedto50Cfor15min.ThesuggesteddilutionforIFis1:100foracetoneorparaformaldehydefixedcellsortissue.Biosensisrecommendsthattheoptimalworkingdilutionshouldbedeterminedbytheenduser.SpecificitySpecificityconfirmedbyWBandIFusingtransfectedcells,Presenilin1knock-outmousecells,mouseandhumanbrain.SpeciesAgainstHuman;mouse;rat;guineapig.Expectedtocross-reactwithotherspeciesduetosequencehomology.BlastURLClickhereConjugateDiptheriatoxoidcovalentlylinkedtoadditionalCysresidueusingmaleimidocaproyl-N-hydroxysuccinimideFormLyophilizedfromPBS,pH7.4.Containsnopreservative.ReconstitutionReconstitutein500µLofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageShorttermstorageat2-8°Cforoneweek.At-20°Casanundilutedliquidforupto12months.ExpiryDate12monthsafterpurchaseReferences1.Culvenor,J.G.,Ilaya,N.T.,Ryan,M.T.,Canterford,L.,Hoke,D.,Williamson,N.A.,McLean,C.A.,Masters,C.L.,and1.Evin,G.(2004)CharacterizationofPresenilincomplexfrommouseandhumanbrainusingBlueNativegelelectrophoresisrevealshighexpressioninembryonicbrainandminimalchangeincomplexmobilitywithPresenilinmutations.Eur.J.Biochem.271,375-385.2.Ilaya,N.T.,Evin,G.,Masters,C.L.,andCulvenor,J.G.(2004)Nicastrinexpressioninmouseperipheraltissuesisnotco-ordinatedwithPresenilinandishighinmuscle.J.NeuRochem.91,230-237.3.Beher,D.,Fricker,M.,NADIn,A.,Clarke,E.E.,Wrigley,J.D.J.,Li,Y.-M.,CULVENOR,J.G.,Masters,C.L.,Harrison,T.,andShearman,M.S.(2003)InvitroCharacterizationofthePresenilin-dependentγ-secretasecomplexusinganovelaffinityligand.Biochem.42,8133-8142.4.Evin,G.,Smith,M.J.,Tziotis,A.,McLean,C.,Canterford,L.,Sharples,R.A.,Cappai,R.,Weidemann,A.,Beyreuther,K.,Cotton,R.G.H.,Masters,C.L.,andCulvenor,J.G.(2002)AlternativetranscriptsofPresenilin-1associatedwithFrontotemporalDementia.NeuroReport13,917-921.5.Silveyra,M.-X.,Evin,G.,Montenegro,M.-F.,Vidal,C.J.,Martínez,S.,Culvenor,J.G.,andSáez-Valero,J.(2008)Presenilin-1interactswithacetylcholinesteraseandaltersitsenzymaticactivityandglycosylation.Mol.CellBiol.210,788-792.

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。