首页 > Biosensis > Biosensis/Rabbit polyclonal antibody to Presenilin 1 loop region: IgG/R-1680-500/500 ug

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Biosensis/Rabbit polyclonal antibody to Presenilin 1 loop region: IgG/R-1680-500/500 ug

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DescriptionPresenilin-1(PSEN1)isamulti-passmembraneproteinandcomponentofthegamma-secretasecomplex.PSEN1isthoughttoplayaroleinintracellularsignalingandgeneexpressionorinlinkingchromatintothenuclearmembrane.Itmayalsoplayaroleinhematopoiesis.DefectsinPSEN1areacauseofAlzheimerdiseasetype3(AD3),afamilialearly-onsetformofAlzheimerdisease(Ref:SWISS-Prot).BatchNo.SeeproductlabelUnitsize500ugAntigenAsyntheticpeptide(GDPEAQRRVSKNSKYNA-C)correspondingtohumanPS1[301-317]intheloopregionconjugatedviaadditionalC-terminalCystoDiphtheriatoxoid.AntibodyTypePolyclonalOtherNamesPresenilin1;PS-1;ProteinS182;PS1-CTF12;PSEN1;AD3;PS1;PSNL1ProducedinRabbitApplicationsWesternBlot.Suggesteddilutionof1:1,000isrecommendedforWB.Fulllengthpresenilin1(467aa)hasrelativeMWofabout45kDa,withthisantibodymostcommonlydetectedascleavedCTFof19kDa.Humanormousebrainsamplescommonlypreparedwithreducingagent(50mMDTT),urea(2.3M),SDS(1.5%)in62.5mMTris-HCLpH6.8samplebuffer(withoutboiling)heatingto50Cfor15min.Biosensisrecommendsthattheoptimalworkingdilutionshouldbedeterminedbytheenduser.SpecificityConfirmedbyWesternblottingusingtransfectedcells,presenilin1knock-outmousecellsandmouseandhumanbrain.SpeciesAgainstHuman;mouse;rat;guineapig.Presenilinproteinsarehighlyconserved,socross-reactivitywithotherspeciesisexpected.FormLyophilizedfromPBS,pH7.4.Containsnopreservative.ReconstitutionReconstitutein500µLofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageShorttermstorageat2-8°Cforoneweek.At-20°Casanundilutedliquidforupto12months.ExpiryDate12monthsafterpurchaseReferencesCulvenor,J.G.,Ilaya,N.T.,Ryan,M.T.,Canterford,L.,Hoke,D.,Williamson,N.A.,McLean,C.A.,Masters,C.L.,and1.Evin,G.(2004)CharacterizationofPresenilincomplexfrommouseandhumanbrainusingBlueNativegelelectrophoresisrevealshighexpressioninembryonicbrainandminimalchangeincomplexmobilitywithPresenilinmutations.Eur.J.Biochem.271,375-385.Ilaya,N.T.,Evin,G.,Masters,C.L.,andCulvenor,J.G.(2004)Nicastrinexpressioninmouseperipheraltissuesisnotco-ordinatedwithPresenilinandishighinmuscle.J.NeuRochem.91,230-237.3.Beher,D.,Fricker,M.,NADIn,A.,Clarke,E.E.,Wrigley,J.D.J.,Li,Y.-M.,Culvenor,J.G.,Masters,C.L.,Harrison,T.,andShearman,M.S.(2003)InvitroCharacterizationofthePresenilin-dependentγ-secretasecomplexusinganovelaffinityligand.Biochem.42,8133-8142.Evin,G.,Smith,M.J.,Tziotis,A.,McLean,C.,Canterford,L.,Sharples,R.A.,Cappai,R.,Weidemann,A.,Beyreuther,K.,Cotton,R.G.H.,Masters,C.L.,andCulvenor,J.G.(2002)AlternativetranscriptsofPresenilin-1associatedwithFrontotemporalDementia.NeuroReport13,917-921.Evin,G.,Sharples,R.A.,Weidemann,A.,Reinhard,F.B.M.,Carbone,V.,Culvenor,J.G.,Holsinger,R.M.D.,Sernee,M.F.,Beyreuther,K.,andMasters,C.L.(2001)AspartylproteaseinhibitorpepstatinbindstothepresenilinsofAlzheimer"sdisease.Biochem.40,8359-8368.

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。