首页 > Biosensis > Biosensis/Sheep antibody to alpha synuclein (116-131): affinity purified/S-075-50/50 µg

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Biosensis/Sheep antibody to alpha synuclein (116-131): affinity purified/S-075-50/50 µg

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S-075-50

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DescriptionAlphasynucleinisanabundant140aminoacidneuronalprotein,expressedprimarilyatpresynapticterminalsinthecentralnervoussystem.Alphasynucleinhasbeenassociatedwithseveralneurodegenerativediseases.Apointmutationinthegenecodingforthealpha-synucleinproteinwasthefirstdiscoverylinkingthisproteintoararefamilialformofParkinson"sdisease(PD).Subsequently,othermutationsinthealpha-synucleingenehavebeenidentifiedinfamilialPD.TheaggregatedproteinaceousinclusionscalledLewybodiesfoundinPDandcorticalLewybodydementia(LBD)werediscoveredtobepredominantlyalpha-synuclein.Aberrantaggregationofalpha-synucleinhasbeendetectedinanincreasingnumberofneurodegenerativediseases,collectivelyknownassynucleopathies.Alpha-synucleinexistsphysiologicallyinbothsolubleandmembrane-boundstates,inunstructuredandalpha-helicalconformations,respectively.Thephysiologicalfunctionofalpha-synucleinappearstorequireitstranslocationbetweenthesesubcellularcompartmentsandinterconversionbetweenthe2conformations.Abnormalprocessingofalpha-synucleinispredictedtoleadtopathologicalchangesinitsbindingpropertiesandfunction.BatchNo.SeeproductlabelUnitsize50µgAntigenAsyntheticpeptide(CMPVDPDNEAYEMPSEE)ofhumanalphasynucleinprotein(aa:116-131)conjugatedtodiphtheriatoxoidhasbeenusedastheimmunogen.OtherNamesNon-AbetacomponentofADamyloid;Non-A4componentofamyloidprecursor;NACPAccessionSYUA_HUMANProducedinSheepPurityAffinitypurifiedanddialysedagainstphosphatebufferedsaline(PBS).Contains0.02%sodiumazide.ApplicationsIHC,WB,ELISA.Recommendedtobeusedataconcentrationof1µg/mlforimmunohistochemistry(Paraffinsections);0.5µg/mlforWBandimmunoblot.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThisantiserumspecificallydetectsalphasynuclein.Cross-reactivityThisantibodyisknowntoreactwithalphasynucleinofhuman,mouse,ratandotherrodents.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein50µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Glycerol(1:1)maybeaddedforanadditionalstability.Avoidrepetitivefreeze/thawcycles.ExpiryDate12monthsafterpurchaseSpecificReferences1.KuoY.M.etal.(2010)ExtensiveentericnervoussystemabnormalitiesinmicetransgenicforartificialchromosomescontainingParkinsondisease-associatedalpha-synucleingenemutationsprecedecentralnervoussystemchanges.HumMolGenet.May1;19(9):1633-502.PelkonenA.etal.(2010)Stimulateddopamineoverflowandalpha-synucleinexpressioninthenucleusaccumbenscoredistinguishratsbredfordifferentialethanolpreference.JNeuRochem.2010Aug;114(4):1168-76.3.Alvesetal.(2008)StriatalandnigralpathologyinalentiviralratmodelofMachado-JosephdiseaseHumMolGenet.2008Jul15;17(14):2071-83.References1.Lundvigetal,BrainResMolBrainRes134,3-17(Mar24,2005).2.Bennett,PharmacolTher105,311-31(Mar,2005).3.Vekrellis,etal.,MolNeurobiol30,1-21(Aug,2004).4.Martin,etal.,ProteinPeptLett11,229-37(Jun,2004).5.Doherty,etal.,ActaNeuropathol(Berl)107,169-75(Feb,2004).6.Goedert,CurrOpinGenetDev11,343-51(Jun,2001).7.Saito,etal.,JNeurolSci177,48-59(Aug1,2000).8.LückingC.B.etal.,CellMolLifeSci.2000Dec;57(13-14):1894-908.9.Kahle,etal.,AnnNYAcadSci920,33-41(2000).10.Clayton,etal.,TrendsNeurosci21,249-54(Jun,1998).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。