首页 > Biosensis > Biosensis/Sheep antibody to LRRK2 (946-962): whole serum/S-070-100/100 µl

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Biosensis/Sheep antibody to LRRK2 (946-962): whole serum/S-070-100/100 µl

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S-070-100

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4000-520-616

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DescriptionLRRK2isamemberoftheleucine-richrepeatkinasefamily.Itroleisyetunknownbutitmayplayaroleinthephoshorylationofproteinscentraltoparkinsondiseases.LRRK2containsanankryinrepeatregion,aleucine-richrepeat(LRR)domain,akinasedomain,aDFG-likemotif,aRASdomain,aGTPasedomain,aMLK-likedomainandaWD40domain.LRRK2ispresentinthecytoplasmbutalsoassociateswiththemitochondrialoutermembrane.DefectsinLRRK2arethecauseofParkinsondisease8(PARK8).ÃÂ Parkinsondiseaseischaracterisedbybradykinesia,restingtremor,muscularrigidityandposturalinstABIlity,aswellasbyaclinicallysignificantresponsetotreatmentwithlevodopa.ThepathologyinvolvesthelossofdopaminergicneuronsinthesubstantianigraandthepresenceofLewybodies(intraneuronalaccumulationsofaggregatedproteins),insurvivingneuronsinvariousareasofthebrain.PARK8isanautosomal-dominantlate-onsetparkinsonism,characterizedbyonsetfrom50to65years,withslowprogressionandrelativelybenigncourse.RelatedproductsLeucine-RichRepeatKinase2inhibitorLRRK2-IN-1BatchNo.SeeproductlabelUnitsize100µlAntigenAsyntheticpeptide(LKRKRKILSSDDSLRSS;aa946-962)aspartofhumanLRRK2proteinconjugatedtotheBlueCarrierProteinhasbeenusedastheimmunogen.OtherNamesLeucine-richrepeatserine/threonine-proteinkinase2;Dardarin;LRRK2;PARK8AccessionLRRK2_HUMANProducedinSheepPurityWholeserumApplicationsIHC.Adilutionrangeof1:500-1:10000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificitySpecificityforLRRK2hasbeenconfirmedbyIHC.Cross-reactivityThisantiserumhasbeensuccessfullytestedinhuman.Otherspecieshavenotyetbeentested.BlastitIfyouwouldliketousethisproductinanotherspeciesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstability,andat4ºCwithanappropriateantibacterialagent.ExpiryDate12monthsafterpurchaseReferences1.ZimprichA,etal.Neuron44:601-607(2004).2.OtaT,etal.Nat.Genet.36:40-45(2004).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。