首页 > Biosensis > Biosensis/Rabbit antibody to human Myeloperoxidase (MPO): IgG/R-133-250/250 µg

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Biosensis/Rabbit antibody to human Myeloperoxidase (MPO): IgG/R-133-250/250 µg

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R-133-250

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DescriptionFUNCTION:Partofthehostdefensesystemofpolymorphonuclearleukocytes.ItisresponsIBLeformicrobicidalactivityagainstawiderangeoforganisms.InthestimulatedPMN,MPOcatalyzestheproductionofhypohalousacids,primarilyhypochlorousacidinphysiologicsituations,andothertoxicintermediatesthatgreatlyenhancePMNmicrobicidalactivity.MPOisanimportantMarkerformyeloidcells,fromthepromyelocytestageandtothematureforms.CATALYTICACTIVITY:Donor+H2O2=oxidizeddonor+2H2O.CATALYTICACTIVITY:Cl-+H2O2=HOCl+2H2O.COFACTOR:Binds1calciumionperheterodimer.COFACTOR:Binds1hemeB(iron-protoporphyrinIX)groupcovalentlyperheterodimer.SUBUNIT:Tetrameroftwolightchainsandtwoheavychains.SUBCELLULARLOCATION:Lysosome.ALTERNATIVEPRODUCTS:3namedisoformsproducedbyalternativesplicing.DISEASE:DefectsinMPOarethecauseofmyeloperoxidasedeficiency(MPD).MPDisanautosomalrecessivedefectthatresultsindisseminatedcandidiasis.SIMILARITY:Belongstotheperoxidasefamily.XPOsubfamily.MicrogliaandastrocytesareknowntoexpressMPOaswell.BatchNo.SeeproductlabelUnitsize250µgAntigenMyeloperoxidaseisolatedfromhumanpolymorphonuclearleucocytesOtherNamesMPOAccessionMPO_HUMANProducedinRabbitPurityIgGApplicationsIHC,WB.Adilutionof1:500-1:1000isrecommended.Thisantiserumworkssuperblyforstainingofparaffin-embeddedtissuesectionsfixedinformalin,frozensectionsandcellcytospins.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThisantiserumreactswithhumanmyeloperoxidase.Cross-reactivityHumanBlastitIfyouwouldliketoseethesharedidentitybetweendifferentspeciesorotherproteinsfollowthelinkinAccessionfield,selectthenthesequence(makesurethatyouareselectingthesequencethatyouareinterestedin,asthesequencemaybetheprecursorratherthanthematureproteinforexample)andcopyandpasteitHEREandblast/formatit.FormLyophilisedReconstitutionReconstitutein250µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability.References1.ArberD.A.etal.AmJClinPathol.2001;116:25-332.KimuraSetal.Proteins1988;3:113-20.3.WeilS.C.etal.Science1988;240:790-2.4.LanzaF.JMolMed1998;76:676-81.5.PinkusG.S.ModPathol1991;4:733-41.6.GrayE.etal.BrainPathol.2008Jan;18(1):86-95.7.MakiR.A.etal.JBiolChem.2009Jan30;284(5):3158-69.

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。