首页 > Biosensis > Biosensis/Rabbit antibody to Peroxiredoxin-6 (NSGPx): whole serum/R-169-100/100 µl

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Biosensis/Rabbit antibody to Peroxiredoxin-6 (NSGPx): whole serum/R-169-100/100 µl

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R-169-100

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Biosensis

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DescriptionFUNCTION:Involvedinredoxregulationofthecell.CanreduceH(2)O(2)andshortchainorganic,fattyacid,andphospholipidhydroperoxides.Mayplayaroleintheregulationofphospholipidturnoveraswellasinprotectionagainstoxidativeinjury. SUBUNIT:Homotetramer.SUBCELLULARLOCATION:Cytoplasm.Lysosome.Alsofoundinlungsecretoryorganelles.MISCELLANEOUS:Theactivesiteistheredox-activeCys-47oxidizedtoCys-SOH.Cys-SOHmayrapidlyreactwithaCys-SHoftheothersubunittoformanintermoleculardisulfidewithaconcomitanthomodimerformation.Theenzymemaybesubsequentlyregeneratedbyreductionofthedisulfidebythioredoxin.MISCELLANEOUS:IrreversIBLyinactivatedbyoveroxidationofCys-47(toCys-SO(3)H)uponoxidativestress.SIMILARITY:BelongstotheahpC/TSAfamily.Rehydrinsubfamily.BatchNo.SeeproductlabelUnitsize100µlAntigenRatrecombinantPeroxiredoxin-6.Thesequenceishomologousinhumanandmouseperoxiredoxin-6.OtherNamesNon-seleniumglutathioneperoxidase;antioxidantprotein2;1-Cysperoxiredoxin;1-CysPRX;Acidiccalcium-independentphospholipaseA2;NSGPx;Thiol-specificantioxidantprotein;Prdx6;Aipla2;Aop2;TsaAccessionPRDX6_RATPRDX6_HUMANPRDX6_MOUSEProducedinRabbitPurityWholeserumApplicationsIHC,WB,ELISA.ThisantibodyworkssuperblyinImmunohistochemistryonfrozenorparaffinembeddedtissues.Antigenretrievalhasbeenusedintestingbutmaynotbenecessary.Typicalworkingdilutionsforroutineimmunohistochemistryare1:100to1:1000dependingontissueanddetectionmethod.Forwesternblottingadilutionrangeof1:1000to1:4000isrecommended.Adilutionof1:1000to1:4000isrecommendedforELISA.Thisantiserumstainsthecytoplasmofepithelialcellsintheratandmouselungandratandhumanbrainastrocytes.ItstainshumanbrainastrocytesinParkinson'sandAlzheimer'sdiseaseandthecentralcoreofsomeLewybodiesinParkinson'sdiseaseanddementiawithLewybodies.Othertissueshavenotyetbeentested.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThisantibodyhasbeenshowntobespecificforPeroxiredoxin-6protein.Cross-reactivityRat,humanandmouse,otherspecieshavenotyetbeentested.BlastitIfyouwouldliketousethisproductinanotherspeicesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20°CforahigherstABIlity,andat4°Cwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability.ExpiryDate12monthsafterpurchaseSpecificReferences1.WalshB.etal.(2010)OverexpressionofPrdx6andresistancetoperoxide-induceddeathinHepa1-6cells:Prdxsuppressionincreasesapoptosis.RedoxRep.2009;14(6):275-84.2.GardinerF.etal.(2010)InductionofPrdx1andPrdx6inLiverCellsbySerumandTPA.IntlJ.Biol.Vol.2,No.1References1.KimT.-S,etal.J.Biol.Chem.272:2542-2550(1997).2.ChoiH.-J,etal.Nat.Struct.Biol.5:400-406(1998).3.RushJ,etal.Nat.Biotechnol.23:94-101(2005).4.WagnerE,etal.Biochem.J.366:777-785(2002).5.ChenJ.-W,etal.J.Biol.Chem.275:28421-28427(2000).6.KangS.W,etal.J.Biol.Chem.273:6303-6311(1998).7.GevaertK,etal.Nat.Biotechnol.21:566-569(2003).8.GregoryS.G,etal.ature441:315-321(2006).9.NagaseT,etal.DNARes.2:37-43(1995).10.FrankS,etal.Oncogene14:915-921(1997).11.PowerJ,etal.AmJ.Path.161:885-894(2202).12.PowerJ,etal.ExperimentalLungRes.25:379-391(1999).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。