首页 > Biosensis > Biosensis/Rabbit antibody to superoxide dismutase (SOD1; 121-139): whole serum/R-168-100/100 µl

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Biosensis/Rabbit antibody to superoxide dismutase (SOD1; 121-139): whole serum/R-168-100/100 µl

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R-168-100

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DescriptionSOD1bindscopperandzincionsansisoneoftwoisozymesresponsIBLefordestroyingfreesuperoxiderADIcalswhicharenormallyproducedwithinthecellsandwhicharetoxictoBIOLOGicalsystems.SOD1isasolublecytoplasmicprotein,actingasahomodimertoconvertsuperoxideradicalstomolecularoxygenandhydrogenperoxide.DefectsinSOD1arethecauseofamyotrophiclateralsclerosistype1(ALS1)whichisaneurodegenerativedisorderaffectingupperandlowermotorneuronsandresultinginfatalparalysis.BatchNo.SeeproductlabelUnitsize100µlAntigenApeptide(HEKADDLGKGGNEESTKTG)correspondingtotheaminoacids121-139ofhumansuperoxidedismutase(SOD1)conjugatedtodiphtheriatoxinhasbeenusedastheimmunogen.OtherNamesSuperoxidedismutase;SOD1;AccessionSODC_HUMANProducedinRabbitPurityWholeserumApplicationsIHC,WB.Thisantibodyworkssuperblyinimmunohistochemistryonfrozenorparaffinembeddedtissues.Antigenretrievalhasbeenusedintestingbutmaynotbenecessary.Typicalworkingdilutionsforroutineimmunohistochemistryare1:100to1:1000dependingontissueanddetectionmethod.Forwesternblottingadilutionrangeof1:1000to1:4000isrecommended.Biosensisrecommendsoptimaldilutions/concentrationsshouldbedeterminedbytheenduser.SpecificityThisantibodyhasbeenshowntobespecificforsuperoxidedismutase(SOD1)protein.Cross-reactivityHuman.DoesnotdetectmouseandratSOD1.BlastitIfyouwouldliketousethisproductinanotherspeicesotherthanthosespecifiedhere,ortoseethesharedidentitybetweentheimmunogenusedhereindifferentspeicesand/orothermolecules,simplycopytheimmunogen(fromtheImmunogenfield)andpasteitHEREandblast/formatit.Notethat,antiseraraisedagainstsyntheticpeptidesarequiteoftenveryspecificforthatpeptideie,onlyonesingleaminoaciddifferencemaybeenoughtorestrictthespecificitytoaparticularmolecule.Regardless,youcanalwayscontactusifyouneedassistancewiththis.FormLyophilisedReconstitutionReconstitutein100µlofsterilewater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionkeepaliquotsat-20ºCforahigherstABIlity,andat4ºCwithanappropriateantibacterialagent.Avoidrepetitivefreeze/thawcycles.Glycerol(1:1)maybeaddedforanadditionalstability.ExpiryDate12monthsafterpurchaseReferences1.JabuschJ.R,etal.Biochemistry19:2310-2316(1980).2.LevanonD,etal.EMBOJ.4:77-84(1985).

Biosensis是一家由生命科学家和商业团队组成的公司，致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验，并在生命科学研究和诊断市场的生命科学抗体，试剂和试剂盒的商业化方面拥有50多年的经验。