

提醒:代购产品,无质量问题不接受退换货,下单前请仔细核对信息。下单后请及时联系客服
核对商品价格,订单生效后再付款。
Biosensis/Chicken polyclonal to Lamin A/C/C-1698-100/100 uL
价格:
自营商城
解放采购
正品保障
及时交付
厂家直采
一站服务
货号:
品牌:
会员服务:
尊享会员价
贵宾专线
运费优惠
闪电退款
福利优惠
上门换新
友情提示
以上价格仅为参考,请联系客服询价。
免费咨询热线
4000-520-616
产品说明
DescriptionTheLaminproteinsaremembersoftheintermediatefilamentproteinfamilybutarelocatedinsidethenucleusratherthaninthecytoplasm(1).Thelaminsfunctionasskeletalcomponentstightlyassociatedwiththeinnernuclearmembrane.OriginallytheproteinsofthenuclearCytoskeletonwerenamedLaminA,BandC,fromtoptobottomasvisualizedonSDS-PAGEgels.SubsequentlyitwasfoundthatLaminsAandCwerecodedforbyasinglegene(2),whiletheLaminBbandmaycontaintwoproteinsencodedbytwogenesnowcalledLaminB1andLaminB2.LaminAhasamassofabout74kDawhileLaminCis65kDa.TheLaminAproteinincludes98aminoacidsmissingfromLaminC,whileLaminChasaC-terminal6aminoacidpeptidenotpresentinLaminA.ApartfromtheseregionsLaminAandCareidenticalsothatantibodiesraisedagainsteitherproteinarelikelytocrossreactwiththeother,asisthecasewiththismonoclonal.Laminpolymerizationanddepolymerizationisregulatedbyphosphorylationbycyclindependentproteinkinase1(CDK1),thekeycomponentof"maturationpromotingfactor",thecentralregulatorofcelldivision.ActivityofthiskinaseincreasesduringcelldivisionandisresponsIBLeforthebreakdownofthenuclearlamina.MutationsintheLMNAgeneareassociatedwithseveralserioushumandiseases,includingEmery-Dreifussmusculardystrophy,familialpartiallipodystrophy,limbgirdlemusculardystrophy,dilatedcardiomyopathy,Charcot-Marie-Toothdiseasetype2B1,andHutchinson-Gilfordprogeriasyndrome.ThisfamilyofdiseasesbelongtoalargergroupwhichareoftenreferredtoasLaminopathies,thoughsomelaminopathiesareassociatedindefectsinLaminB1,B2oroneorotherofthenumerousnuclearlaminabindingproteins.AtruncatedversionoflaminA,commonlyknownasprogerin,causesHutchinson-Gilfordprogeriasyndrome,aformofprematureaging(3).BatchNo.SeeviallabelUnitsize100uLAntigenFulllengthrecombinanthumanLaminCAntibodyTypePolyclonalProducedinChickenApplicationsImmunocytochemistry(ICC)andWesternBlotting(WB).Adilutionof1:1,000-1:2,000isrecommendedforWB.Adilutionof1:500-1:1,000isrecommendedforICC.Theoptimaldilutionshouldbedeterminedbytheenduser.SpecificityLaminAandLaminC.Theantibodyreactswitha74kDaand65kDabandbyWesternblotonHeLacellextract.IthasalsobeenusedsuccessfullyforimmunocytochemistryonHeLacellcultures.SpeciesAgainstHuman,bovine,porcine,mouseandrat.Itisexpectedthatitwillworkonothermammaltissues.FormLyophilizedfromPBS.Contains5%trehaloseand0.5%sodiumazide.AppearanceWhitepowderReconstitutionReconstituteinsteriledistilledwater.Centrifugetoremoveanyinsolublematerial.StorageAfterreconstitutionoflyophilizedantibody,aliquotandstoreat-20°CforahigherstABIlity.Avoidfreeze-thawcycles.ExpiryDate12monthsafterpurchaseGeneralReferences1.Fisher,D.Z.,Chaudhary,N.,Blobel,G.CDNAsequencingofnuclearlaminsAandCrevealsprimaryandsecondarystructuralhomologytointermediatefilamentproteins.Proc.Nat.Acad.Sci.83:6450-6454(1986).2.McKeon,F.D.,Kirschner,M.W.,Caput,D.Homologiesinbothprimaryandsecondarystructurebetweennuclearenvelopeandintermediatefilamentproteins.Nature319:463-468(1986).3.Liu,B.andZhou,Z.LaminA/C,laminopathiesandprematureageing.Histol.Histopathol.23:747-763(2006).
Biosensis是一家由生命科学家和商业团队组成的公司,致力于为全球学术界和工业界的研究人员提供支持。该团队在基础和应用生命科学研究方面拥有超过100年的经验,并在生命科学研究和诊断市场的生命科学抗体,试剂和试剂盒的商业化方面拥有50多年的经验。
新品排行榜
1
Biosensis/Human MMP-7 ELISA Kit ...
2
Biosensis/Rabbit antibody to Sap...
3
Biosensis/Rabbit polyclonal anti...
4
Biosensis/Mouse antibody to MANF...
5
Biosensis/Rabbit polyclonal anti...
6
Biosensis/Rabbit polyclonal anti...
7
Biosensis/Rabbit antibody to hum...
8
Biosensis/Rabbit polyclonal anti...
9
Biosensis/Rabbit polyclonal anti...
10
Biosensis/Rabbit polyclonal anti...
文章排行榜
1
Biosensis/Rat BDNF ELISA Kit (2 plates)/BEK-2000-2P/1 Ea
2
Biosensis/Mouse monoclonal antibody to Lysosomal Associated Membrane Protein 1 [LAMP1]/M-1690-100/1
3
Biosensis/Mouse monoclonal antibody to human Epidermal growth factor-like 1[2F7]: IgG/M-812-100/100
4
Biosensis/Rat Growth-regulated alpha protein ELISA Kit (2 plates)/BEK-2123-2P/1 Ea
5
Biosensis/Mouse monoclonal antibody to DJ-1 [PARK7]: IgG/M-1573-100/100 µg
6
Biosensis/NGF Rapid ELISA Kit: Human (1 Plate)/BEK-2212-1P/1 Ea
7
Biosensis/Mouse NT3 ELISA Kit (2 plates)/BEK-2079-2P/1 Ea
8
Biosensis/Mouse C-C motif chemokine 2 ELISA Kit (2 plates)/BEK-2186-2P/1 Ea
9
Biosensis/GDNF Rapid ELISA Kit: Human (1 plate)/BEK-2222-1P/1 Ea
10
Biosensis/Parkin control peptide (305-323)/PE-1253-100/100 µg
微信公众号

手机扫码,关注动态