首页 > Rockland > Rockland/APC1 phospho S355 Antibody/600-401-856/100 µg

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Rockland/APC1 phospho S355 Antibody/600-401-856/100 µg

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600-401-856

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.detail-leftcolumn { float: left; font-weight: bold; width: 200px; } .detail-rightcolumn { float: left; width: 340px; } .detail-text-title2 { /* float: left; */ font-weight: bold; width: 200px; }APC1phosphoS355AntibodyPropertiesDescriptionAnti-APC1pS355(RABBIT)Antibody-600-401-856HostRabbitTargetSpeciesHumanKnownCrossReactivityhuman,mouse,dog,rat,bovineClonalityPolyclonalApplicationELISA:1:10,000-1:35,000WesternBlot:1:200-1:2,000ImmunoPrecipitation:1:100OtherDilution:UserOptimizedPhysicalStateLiquid(sterilefiltered)ShippingConditionDryIceFormatIgGLabelUnconjugatedConcentration1.0mg/mLbyUVabsorbanceat280nmBuffer0.02MPotassiumPhosphate,0.15MSodiumChloride,pH7.2Preservative0.01%(w/v)SodiumAzideStABIlizerNoneGeneNameANAPC1,TSG24RelevantLinksNCBI-12056971UniProtKB-Q9H1A4GeneID-64682APC1phosphoS355AntibodyDescriptionBackgroundAPC1(alsoknownasAnaphasepromotingcomplexsubunit1,Cyclosomesubunit1,ProteinTsg24,MitoticcheckpointregulatorandANAPC1)is1ofatleast11subunitsoftheanaphase-promotingcomplex(APC),whichfunctionsatthemetaphase-to-anaphasetransitionofthecellcycleandisregulatedbyspindlecheckpointproteins.TheAPCisanE3ubiquitinligasethattargetscellcycleregulatoryproteinsfordegradationbytheproteasome,therebyallowingprogressionthroughthecellcycle.Synonymsrabbitanti-APC1pS355Antibody,Anaphase-promotingcomplexsubunit1,APC-1,APC1,Cyclosomesubunit1,Testis-specificgene24protein,MitoticcheckpointregulatorImmunogenThisaffinitypurifiedantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacids351-359ofHumanApc1protein.ImmunogenTypePeptidePostTranslationalModificationPhosphorylationStorageConditionStorevialat-20°Cpriortoopening. Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage. Avoidcyclesoffreezingandthawing. Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature. Thisproductisstableforseveralweeksat4°Casanundilutedliquid. Diluteonlypriortoimmediateuse.ApplicationNoteThisaffinitypurifiedantibodyhasbeentestedforuseinELISAandwesternblot. Specificconditionsforreactivityshouldbeoptimizedbytheenduser.Expectaband~215kDainsizecorrespondingtoAPC1bywesternblottingintheappropriatecelllysateorextract.Purity/SpecifityThisproductisanaffinitypurifiedantibodyproducedbyimmunoaffinitychromatographyusingphosphopeptidecoupledtoagarosebeadsfollowedbysolidphaseadsorption(s)againstnon-phosphopeptideandnon-specificpeptidetoremoveanyunwantedreactivities.ThisantibodyisspecificforphosphorylatedhumanAPC1proteinatthepS355residue.ABLASTanalysiswasusedtosuggestreactivitywiththisproteinfromhuman,mouse,dog,rat,andbovinebasedon100%homologyfortheimmunogensequence.CrossreactivitywithAPC1proteinfromchimpanzeeandchickenisexpectedasthesequenceoftheimmunogenonlyvariesbyoneaminoacidinfromthesesources(89%homology).CrossreactivitywithAPC1homologuesfromothersourceshasnotbeendetermined. Minimalreactivityisexpectedwiththenon-phosphorylatedformoftheprotein.DisclaimerNote-GeneralThisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

美国Rockland是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物，全部按美国农业部实验动物规范饲养和操作，是近20年来美国少数几家成功的大型实验动物商业基地。其产品通过贴牌委托生产，国际代理商和直销等方式行销全球。其中最著名的是全线二抗产品，以全面，价格合理为特色。今年，Rockland也加大了在一抗方面的投资力度，新生物分子的抗体数量每年都大幅增长，而这又是以其强大的重组蛋白表达能力为基础的。

美国Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。Rockland还对部分设施进行了GMP改造，以吸引大型制药厂的委托订单。同时又以GMP标准为蓝图，提高其他产品的质量标准和管理水平。

Rockland还不断与时俱进，探索其他扩展产品线的渠道。利用周边广布著名高校和研究机构的便利，Rockland加快和科研单位合作，从深度和广度两维加速开发新产品，正在从一个OEM老厂走到前台，缩短与直接客户的距离。