首页 > Rockland > Rockland/Apc11 Antibody/100-401-A15/100 µL

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Rockland/Apc11 Antibody/100-401-A15/100 µL

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100-401-A15

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.detail-leftcolumn { float: left; font-weight: bold; width: 200px; } .detail-rightcolumn { float: left; width: 340px; } .detail-text-title2 { /* float: left; */ font-weight: bold; width: 200px; }Apc11AntibodyPropertiesDescriptionAnti-APC11(C-terminalspecific)(RABBIT)Antibody-100-401-A15HostRabbitTargetSpeciesHumanKnownCrossReactivityhumanClonalityPolyclonalApplicationELISA:1:2,000-1:10,000WesternBlot:1:500-1:1,000Immunohistochemistry:UserOptimizedOtherDilution:UserOptimizedPhysicalStateLiquid(sterilefiltered)ShippingConditionDryIceFormatAntiserumLabelUnconjugatedConcentration85mg/mLbyRefractometryBufferNonePreservative0.01%(w/v)SodiumAzideStABIlizerNoneGeneNameANAPC11RelevantLinksUniProtKB-Q9NYG5NCBI-19924286GeneID-51529Apc11AntibodyDescriptionBackgroundAPC11isalsoknownasAnaphasepromotingcomplexsubunit11,APC11,Cyclosomesubunit11,HepatocellularcarcinomaassociatedRINGfingerprotein,andHSPC214. APC11isacomponentoftheanaphasepromotingcomplex/cyclosome(APC/C),acellcycle-regulatedE3ubiquitinligasethatcontrolsprogressionthroughmitosisandtheG1phaseofthecellcycle.APC11mayfunctiontorecruittheE2ubiquitin-conjugatingenzymestothecomplex. APC11interactswiththecullindomainofANAPC2andalsointeractswithUBE2D2. APC11showsbothacytoplasmicandnuclearlocalization. APC11isexpressedathighlevelsinskeletalmuscleandheart;inmoderatelevelsinbrain,kidney,andliver;andatlowlevelsincolon,thymus,spleen,smallintestine,placenta,lungandperipheralbloodleukocyte. APC11isamemberoftheRING-typezincfingerfamilyandisauto-ubiquitinylated.Synonymsrabbitanti-Apc11Antibody,Anaphasepromotingcomplexsubunit11homologantibody,APC11anaphasepromotingcomplexsubunit11homologantibody,Cyclosomesubunit11antibody,HepatocellularcarcinomaassociatedRINGfingerproteinantibody,HSPC214antibody,ApcImmunogenThisantibodywaspreparedfromwholerabbitserumproducedbyrepeatedimmunizationswithasyntheticpeptidecorrespondingtoaminoacids76-84ofHumanAPC11(C-terminal)coupledtoKLH.ImmunogenTypePeptideStorageConditionStorevialat-20°Cpriortoopening.Aliquotcontentsandfreezeat-20°Corbelowforextendedstorage.Avoidcyclesoffreezingandthawing.Centrifugeproductifnotcompletelyclearafterstandingatroomtemperature.Thisproductisstableforseveralweeksat4°Casanundilutedliquid.Diluteonlypriortoimmediateuse.ApplicationNoteThisantibodyreactswithhumanAPC11bywesternblotandimmunoprecipitation. Theantibodyimmunoprecipitatesinvitrotranslatedproteinandproteinfromoverexpressingcelllysates(usingHeLaandNIH-3T3,andothers). Coimmunoprecipitationofrelatedproteins(APC2)doesoccur. A9.8kDabandcorrespondingtohumanAPC11isdetected.MostcelllinesortissuesexpressingAPC11canbeusedasapositivecontrol. Researchersshoulddetermineoptimaltitersforotherapplications.Purity/SpecifityThisproductismonospecificantiserumprocessedbydelipidationanddefibrinationfollowedbysterilefiltration.ThisproductreactswithhumanandmouseAPC11.CrossreactivitymayalsooccurwithAPC11fromothersources. SufficientsequencedifferencesexisttosuggestthatthisantibodywouldnotreactwithotherRINGboxproteinssuchasROC1andROC2.DisclaimerNote-GeneralThisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

美国Rockland是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物，全部按美国农业部实验动物规范饲养和操作，是近20年来美国少数几家成功的大型实验动物商业基地。其产品通过贴牌委托生产，国际代理商和直销等方式行销全球。其中最著名的是全线二抗产品，以全面，价格合理为特色。今年，Rockland也加大了在一抗方面的投资力度，新生物分子的抗体数量每年都大幅增长，而这又是以其强大的重组蛋白表达能力为基础的。

美国Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。Rockland还对部分设施进行了GMP改造，以吸引大型制药厂的委托订单。同时又以GMP标准为蓝图，提高其他产品的质量标准和管理水平。

Rockland还不断与时俱进，探索其他扩展产品线的渠道。利用周边广布著名高校和研究机构的便利，Rockland加快和科研单位合作，从深度和广度两维加速开发新产品，正在从一个OEM老厂走到前台，缩短与直接客户的距离。