首页 > Rockland > Rockland/ABCA4 Rim Protein Antibody/200-301-D05/100 µL

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Rockland/ABCA4 Rim Protein Antibody/200-301-D05/100 µL

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200-301-D05

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.detail-leftcolumn { float: left; font-weight: bold; width: 200px; } .detail-rightcolumn { float: left; width: 340px; } .detail-text-title2 { /* float: left; */ font-weight: bold; width: 200px; }ABCA4RimProteinAntibodyPropertiesDescriptionAnti-ABCA4(RimProtein)(Mouse)MonoclonalAntibody-200-301-D05HostMouseTargetSpeciesBovineKnownCrossReactivitybovine,human,mouse,XenopusClonalityMonoclonal3F4IgGApplicationELISA:1:10,000WesternBlot:1:1000Immunohistochemistry:1:100PhysicalStateLiquidShippingConditionDryIceFormatIgGLabelUnconjugatedBuffer0.01MHEPES,0.15MSodiumChloride,pH7.5StABIlizer0.1mg/mlBovineSerumAlbumin(BSA)-IgGandProteasefree,50%(v/v)GlycerolGeneNameABCA4RelevantLinksUniProtKB-O35600GeneID-11304NCBI-NP_776646.1ABCA4RimProteinAntibodyDescriptionBackgroundABCA4antibodydetectsABCA4(ATP-bindingcassette,sub-familyA(ABC1),member4,RimProtein)amemberofthesuperfamilyofATP-bindingcassette(ABC)transporters.ABCproteinstransportvariousmoleculesacrossextra-andintracellularmembranes.ABCA4isaretina-specificABCtransporterwithN-retinylidene-PEasasubstrate.Itisexpressedexclusivelyinretinaphotoreceptorcells,indicatingthegeneproductmediatestransportofanessentialmoleculeacrossthephotoreceptorcellmembrane.MutationsinthisgenearefoundinpatientsdiagnosedwithStargardtdiseaseandareassociatedwithretinitispigmentosa-19andage-relatedmaculardegeneration.DefectsinABCA4arethecauseofStargardtdiseasetype1(STGD1).STGDisoneofthemostfrequentcausesofmaculardegenerationinchildhood.DefectsinABCA4arealsoknowntocausefundusflavimaculatus(FFM),age-relatedmaculardegenerationtype2(ARMD2)andcone-roddystrophytype3(CORD3).Anti-ABCA4antibodyisidealforinvestigatorsinvolvedinCellSignaling,Neuroscience,SignalTransductionresearch.SynonymsRetinal-specificATP-bindingcassettetransporter,ATP-bindingcassettesub-familyAmember4,RIMABCtransporterImmunogenAnti-ABCA4antibodywasproducedbyrepeatedimmunizationswithpartiallypurifiedbovine220-kDadiscrimprotein.ImmunogenTypeNativeProteinStorageConditionStorevialat-20°Cpriortoopening. Thisproductisstableat4°Casanundilutedliquid. Forextendedstorage,aliquotcontentsandfreezeat-20°Corbelow. Avoidcyclesoffreezingandthawing.Diluteonlypriortoimmediateuse.ApplicationNoteAnti-ABCA4antibodyissuitableforuseinELISA,WesternBlottingandIHC.Specificconditionsshouldbeoptimizedbytheenduser.Expectabandof~250kDainsizecorrespondingtoABCA4proteinsintheappropriatecelllysateorextract.Purity/SpecifityAnti-ABCA4antibodyisdirectedagainstbovineABCA4RimProtein.TheantibodywasProteinGpurifiedfromculturesupernatant.Reactivityisexpectedagainsthuman,mouseandXenopus.Cross-reactivitywithABCA4fromothersourceshasnotbeendetermined.DisclaimerNote-GeneralThisproductisforresearchuseonlyandisnotintendedfortherapeuticordiagnosticapplications.Pleasecontactatechnicalservicerepresentativeformoreinformation.AllproductsofanimaloriginmanufacturedbyRocklandImmunochemicalsarederivedfromstartingmaterialsofNorthAmericanorigin.CollectionwasperformedinUnitedStatesDepartmentofAgriculture(USDA)inspectedfacilitiesandallmaterialshavebeeninspectedandcertifiedtobefreeofdiseaseandsuitableforexportation.Allpropertieslistedaretypicalcharacteristicsandarenotspecifications.Allsuggestionsanddataareofferedingoodfaithbutwithoutguaranteeasconditionsandmethodsofuseofourproductsarebeyondourcontrol.Allclaimsmustbemadewithin30daysfollowingthedateofdelivery.TheProspectiveusermustdeterminethesuitabilityofourmaterialsbeforeadoptingthemonacommercialscale.SuggestedusesofourproductsarenotrecommendationstouseourproductsinviolationofanypatentorasalicenseunderanypatentofRocklandImmunochemicals,Inc.Ifyourequireacommerciallicensetousethismaterialanddonothaveone,thenreturnthismaterial,unopenedto:RocklandInc.,P.O.BOX5199,Limerick,Pennsylvania,USA.

美国Rockland是一家老牌抗体原产企业，其位于美国费城郊区的农场保有近20种实验动物，全部按美国农业部实验动物规范饲养和操作，是近20年来美国少数几家成功的大型实验动物商业基地。其产品通过贴牌委托生产，国际代理商和直销等方式行销全球。其中最著名的是全线二抗产品，以全面，价格合理为特色。今年，Rockland也加大了在一抗方面的投资力度，新生物分子的抗体数量每年都大幅增长，而这又是以其强大的重组蛋白表达能力为基础的。

美国Rockland公司为生命科学领域提供丰富的、高质量的抗体，包括载脂蛋白、细胞周期/凋亡、细胞因子、细胞信号蛋白、酶类、细胞外基质、转录因子(NFkB)和泛素（Ubiquitin）等识别抗体，应用范围包括Western blot、免疫组化、免疫荧光和ELISA等。另外，Rockland也生产特别齐全的二抗，包括纯化、生物素、HRP/ALP、荧光标记二抗，应用十分广泛。Rockland还对部分设施进行了GMP改造，以吸引大型制药厂的委托订单。同时又以GMP标准为蓝图，提高其他产品的质量标准和管理水平。

Rockland还不断与时俱进，探索其他扩展产品线的渠道。利用周边广布著名高校和研究机构的便利，Rockland加快和科研单位合作，从深度和广度两维加速开发新产品，正在从一个OEM老厂走到前台，缩短与直接客户的距离。