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ProteinTech/Caspase 1/p20/p10 Polyclonal antibody/150ul/22915-1-AP
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Tested ApplicationsPositive WB detected inRAW264.7, Raji cells,MCF-7 cells,NIH/3T3 cells,HeLa cells,C6 cells,Jurkat cellsPositive IHC detected inhuman spleen tissueNote: suggested antigen retrieval with TE buffer pH 9.0; (*) Alternatively, antigen retrieval may be performed with citrate buffer pH 6.0Positive IF detected inC6 cellsRecommended dilutionApplicationDilutionWestern Blot (WB)WB : 1:500-1:2000Immunohistochemistry (IHC)IHC : 1:100-1:400Immunofluorescence (IF)IF : 1:10-1:100Sample-dependent, check data in validation data galleryPublished ApplicationsWBSee 100 publications belowIHCSee 14 publications belowIFSee 14 publications belowProduct InformationThe immunogen of 22915-1-AP is Caspase 1/p20/p10 Fusion Protein expressed in E. coli.Tested Reactivityhuman,mouse,ratCited Reactivity cow, human, mouse, ratHost / IsotypeRabbit / IgGClassPolyclonalTypeAntibodyImmunogenCaspase 1/p20/p10 fusion protein Ag11143Full Namecaspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)Calculated molecular weight 404 aa, 45 kDaObserved molecular weight 45-47 kDa, 30 kDa, 35 kDaGenBank accession numberBC062327Gene symbolCASP1Gene ID (NCBI)834ConjugateUnconjugatedFormLiquidPurification MethodAntigen affinity purificationStorage BufferPBS with 0.02% sodium azide and 50% glycerol pH 7.3.Storage ConditionsStore at -20°C. Stable for one year after shipment. Aliquoting is unnecessary for-20oC storage.Background InformationCASP1(caspase-1) is also named as IL1BC, IL1BCE and belongs to the peptidase C14A family. It is a cysteine protease that regulates inflammatory processes through its capacity to process and activate the interleukin-1-beta (IL1B), IL18, and IL33 precursor proteins. The active caspase-1 can increase cellular membrane permeability and intracellular calcium levels, which facilitates lysosome exocytosis and release of host antimicrobial factors and microbial products(PMID:21804020). It has 5 isoforms produced by alternative splicing. 22915-1-AP can recognize all the five isoforms of caspase 1. It also can recognize p45 procaspase and the mature fragments p10 and p20..ProtocolsProduct Specific ProtocolsWB protocol for Caspase 1/p20/p10 antibody 22915-1-APDownload protocolIHC protocol for Caspase 1/p20/p10 antibody 22915-1-APDownload protocolIF protocol for Caspase 1/p20/p10 antibody 22915-1-APDownload protocolStandard ProtocolsClick here to view our Standard Protocols

Proteintech Group 由一群当时积极从事 NIH 资助研究的科学家于 2001 年创立。最初的创始人之一和现任首席执行官 Jason Li 博士在公司成立期间是伊利诺伊大学芝加哥分校的免疫学副教授。他谈到 Proteintech 成立背后的原因:

“我们抱负的核心是一家由科学家组成的公司;一家为研究人员提供优势的抗体供应商,而不是投资者。”

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Proteintech Group 的部分早期愿景是按照可能的最高标准生产自己的所有产品,并且从不从任何其他供应商处采购单一抗体。这将为研究人员提供许多优势,包括避免由不同公司以不同品牌出售相同抗体的方法——这是行业内出现的一种不受监管的做法1

Proteintech 以 100% 的原创产品为客户提供真诚和正直的品质,您将在本手册中不断发现这些品质。您只能直接从 Proteintech 或通过其批准的经销商之一购买 Proteintech 抗体 - 当您收到抗体并看到小瓶上的 Proteintech 标志时,请知道您拥有真正独一无二的东西。


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