Description:SrctyrosinekinaseinhibitorChemicalName:N-(2-Chloro-5-methoxyphenyl)-6-methoxyPurity:≥99%(HPLC)BIOLOGicalActivityTechnicalDataSolubilityCalculatorsDatasheetsReferencesBiologicalActivitySrctyrosinekinaseinhibitor.Reducestumorsize,vascularityandmetastasis,andincreasesapoptosisinhumanpancreaticcellsgrowninnudemice.Alsoexhibitsantiangiogenicactivityinvitroandinvivo.SensitizestumorcellstothecytotoxiceffectsofgemcitABIne(Cat.No.3259).LicensingInformationSoldwiththepermissionofAstraZenecaUKLtd.CompoundLibrariesAZM475271isalsoofferedaspartoftheTocriscreenPlusandTocriscreenKinaseInhibitorToolboxI.FindoutmoreaboutcompoundlibrariesavailablefromTocris.TechnicalDataM.Wt442.94FormulaC23H27ClN4O3StorageStoreatRTPurity≥99%(HPLC)CASNumber476159-98-5PubChemID5330175InChIKeyWPOXAFXHRJYEIC-UHFFFAOYSA-NSmilesClC1=CC=C(OC)C=C1NC3=NC=NC2=CC(OCC4CCN(C)CC4)=C(OC)C=C23Thetechnicaldataprovidedaboveisforguidanceonly.ForbatchspecificdatarefertotheCertificateofAnalysis.AllTocrisproductsareintendedforlaboratoryresearchuseonly.SolubilityDataSolventMaxConc.mg/mLMaxConc.mMSolubilityDMSO44.29100PreparingStockSolutionsThefollowingdataisbasedontheproductmolecularweight442.94.Batchspecificmolecularweightsmayvaryfrombatchtobatchduetosolventofhydration,whichwillaffectthesolventvolumesrequiredtopreparestocksolutions.Concentration/SolventVolume/Mass1mg5mg10mg1mM2.26mL11.29mL22.58mL5mM0.45mL2.26mL4.52mL10mM0.23mL1.13mL2.26mL50mM0.05mL0.23mL0.45mLMolarityCalculatorMolarityCalculatorCalculatethemass,volume,orconcentrationrequiredforasolution.ReconstitutionCalculatorReconstitutionCalculatorDilutionCalculatorDilutionCalculatorCalculatethedilutionrequiredtoprepareastocksolution.ProductDatasheetsCertificateofAnalysis/ProductDatasheetSafetyDatasheetSelectanotherlanguage:EnglishGermanFrenchSpanishViewSDSReferencesReferencesarepublicationsthatsupporttheproducts'biologicalactivity.Yezhelyevetal(2004)InhibitionofSrctyrosinekinaseastreatmentforhumanpancreaticcancergrowingorthotopicallyinnudemice.Clin.CancerRes.108028PMID:15585638Summyetal(2005)AP23846,anovelandhighlypotentSrcfamilykinaseinhibitor,reducesvascularendothelialgrowthfactorandinterleukin-8expressioninhumansolidtumorcelllinesandabrogatesdownstreamangiogenicprocesses.Mol.CancerTher.41900PMID:16373705Keywords:AZM475271,supplier,AZM475271,inhibits,Src,family,tyrosine,kinase,inhibitors,astrazeneca,Src,Kinases,Src,Kinases,TocrisBioscience
Tocris Bioscience是一家专卖生命科学研究chemicals, peptides and antibodies的知名品牌，其产品也广为各大药厂、大学、研究机构，超过五万名科学研究者所采用。 目前，產品內容已超過一千六百種以上，並每年持續不斷的增加新的產品。目前，产品内容已超过一千六百种以上，并每年持续不断的增加新的产品。
Tocris bioscience是位于英国布里斯托尔（Bristol）的高品质试剂提供商，共有2000多种产品，主要集中在神经科学和信号传导领域，产品类型包括小分子、多肽、抗体、配体和化合物筛选文库等，主要产品包括GPCR ligands，神经传递素，离子通道调控剂，信号通路抑制剂等，这些产品被广泛选择性地用于阻断或激活生物学通路。Tocris是世界上神经科学研究领域无可争议的领导者，其生产的影响神经系统的化学物质被多次引用，这些物质很多都来自Jeff Watkins（Tocris 的创立人）在Bristol大学原创性的研究工作。
Tocris Bioscience的主要产品包括：
Small Molecules
Peptides
Aptamers
Controlled Substances
Compound Libraries
DREADD Ligands
Fluorescent Imaging
Ligand Sets
Optopharmacology
Reagents
Toxins
按照研究领域细分：
Cancer
Cardiovascular System
Endocrinology
Immunology
Neuroscience
Pain & Inflammation
Respiratory System
